Personalized care for patients with familial adenomatous polyposis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the efficacy and safety of a personalized surveillance and intervention protocol for duodenal and gastric polyposis in patients diagnosed with familial adenomatous polyposis (FAP). Given the high risk of duodenal adenomas in FAP patients, the study seeks to improve upon the existing Spigelman classification system, which has limitations in predicting cancer risk. By implementing a tailored approach to surveillance and intervention, the researchers hope to enhance patient outcomes and reduce the need for surgical interventions, which carry significant risks. The study will involve monitoring patients and determining the best course of action based on individual assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of FAP, at least one of following: genetic diagnosis (proven APC germline mutation) and/or clinical diagnosis (\>100 colorectal adenomas in combination with a positive family history of FAP)
* Age 18 years or older

Exclusion Criteria:

* Endoscopic removal of all polyps with an indication for removal not possible/feasible
* Gastric or duodenal cancer at baseline endoscopy
* Need for surgery

Where it's running

• MD Anderson
  Houston, Texas, United States Recruiting
• Academic Medical Centre
  Amsterdam, North Holland, Netherlands Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Classifying duodenal polyps in familial adenomatous polyposis

  This project will test two risk models to see if they better predict dangerous duodenal polyps and cancer risk in people with genetically confirmed FAP.

  Recruiting at 2 sites Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Milan, MI and 1 other locations · NCT07199127

• Personalized home treadmill exercise for people with Familial Adenomatous Polyposis (FAP)

  This trial will try different amounts of home treadmill exercise in people with FAP who have at least five rectal polyps to see if exercise can help prevent polyps from coming back.

  Recruiting University of Michigan Rogel Cancer Center · Ann Arbor, Michigan and 1 other locations · NCT06641310

• Investigating factors that influence polyp development in patients with Familial Adenomatous Polyposis

  This study looks at how gut bacteria and environmental factors might affect polyp growth in people with Familial Adenomatous Polyposis who have had preventive surgery and regular check-ups.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon, France and 1 other locations · NCT06614738

• TPST-1495 treatment for people with familial adenomatous polyposis

  This trial will try an oral drug called TPST-1495 to see if it reduces the number of polyps in the small bowel and colon in people with familial adenomatous polyposis.

  Recruiting at 2 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 3 other locations · NCT06557733

• 10 cm versus 15 cm J-shaped ileal pouch after IPAA surgery

  This trial will see if a 10 cm or a 15 cm J-pouch gives better bowel function and quality of life for people having IPAA for ulcerative colitis or familial adenomatous polyposis.

  Recruiting at 2 sites Odense University Hospital · Aarhus and 1 other locations · NCT06538402

• ONC201 (dordaviprone) for safety and prevention of colorectal polyps in high-risk adults.

  This trial tests whether different doses of ONC201 (dordaviprone) are safe and can help prevent new colorectal polyps in adults with familial adenomatous polyposis or a history of multiple adenomas.

  Recruiting at 3 sites Phase 1 National Cancer Institute (NCI) · Ann Arbor, Michigan and 4 other locations · NCT05630794

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.