Personalized Immunomonitoring for Juvenile Dermatomyositis

Who could benefit from this research

What this research studies

This project focuses on children with juvenile dermatomyositis (JDM), a systemic autoimmune condition that affects the skin, muscles, and sometimes lungs or heart. By studying autoantibodies, immune cell subsets, and interferon activity, researchers aim to map how the disease behaves in individual patients. The team will collect and analyze samples over time to find minimally invasive ways to diagnose and measure disease activity and course. The goal is to move beyond broad immunosuppression to more precise, patient-specific care.

Why it matters

Where this research is happening

• Weill Medical Coll of Cornell Univ
  New York, United States Active

Researchers

• Principal investigator: Pascual, Maria Virginia — Weill Medical Coll of Cornell Univ
• Study coordinator: Pascual, Maria Virginia

Related research

Other NIH-funded projects on the same topics.

• Understanding why Dermatomyositis causes worse outcomes in women

  A patient-centered project to understand why women with dermatomyositis, especially Black women, have more severe disease and death, and to build a regional patient registry to guide better care.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11406169

• Precision therapies for dermatomyositis using single-cell RNA data and bioinformatics

  A doctor-scientist team at a major hospital plans to find existing drugs that could treat dermatomyositis by analyzing patient cells at the single-cell level and testing promising options in the lab.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11322715

• Identifying targeted treatments for dermatomyositis using advanced genetic analysis

  This study is looking at dermatomyositis, a tough autoimmune condition, to find better and safer treatments by examining blood and skin samples from patients to see how their immune system is affected, and then using that information to repurpose existing medications.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11124607

• Understanding how skin and blood cell signals affect treatment response in children with dermatomyositis

  This study is looking at why some kids with juvenile dermatomyositis don’t get better with usual treatments by checking their skin and blood for clues, so we can find better ways to help them feel better.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11077252

• Using a cannabinoid to relieve itching and inflammation in dermatomyositis

  This study is looking at a new treatment that could help reduce the severe itching and inflammation caused by dermatomyositis, an autoimmune disease, and it's designed for people who are dealing with this condition.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10656390

• Anti-CD19/BCMA universal CAR-T cell therapy for refractory autoimmune diseases

  This will try anti-CD19/BCMA universal CAR-T cell therapy in adults with refractory rheumatoid arthritis, dermatomyositis, systemic lupus, or systemic sclerosis to see if it is safe and can control their disease.

  Recruiting The First Affiliated Hospital with Nanjing Medical University · Nanjing, Jiangsu · NCT07558850

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.