Biomarkers that predict how skin-disease treatments will work

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify cellular, molecular, and microbiological factors that predict treatment response at 1 year across several inflammatory skin diseases. It will collect skin samples, blood, and possibly other data from adults with moderate to severe conditions and compare them to healthy controls who have had skin surgery. The study also looks at long-term factors related to disease progression and drug safety over up to 10 years. Findings could guide personalized treatment decisions and inspire new therapeutic targets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients:

* Age\>18 years
* Informed consent signed by the patient
* Diagnosis of moderate to severe chronic inflammatory skin disease (IGA score 3 or 4) including: atopic dermatitis, psoriasis, hidradenitis suppurativa, lichen planus, cutaneous lupus, dermatomyositis, cutaneous scleroderma (=morphea), neutrophilic dermatosis, cutaneous granulomatosis, cutaneaous vasculitis, autoimmune bullous dermatosis
* Or diagnosis of active leprosy (tuberculoid, lepromatous, reversion type 1, reversion type 2, hypersensitivity type 3), excluding pure neurological leprosy. Classification into 5 stages according to the Ridley and Jopling classification \[1\], Reversion reaction (type 1 reaction) and leprous erythema nodosum (type 2 reaction).

Healthy controls :

* Age\>18 years
* Plastic surgery patients who have had any type of surgery resulting in healthy skin remnants
* Informed consent signed by the patient
* Absence of known cutaneous inflammatory disease.

Exclusion Criteria:

* Under guardianship or curatorship
* Pregnant or breastfeeding woman
* Lack of affiliation with a social security system
* Current systemic treatment with immunosupressant (including corticosteroid therapy) or an immunomodulator or received within the last 3 months.

Where it's running

• Hôpital Saint Louis
  Paris, France Recruiting

Study contacts

• Study coordinator: Charles Cassius, MD
• Email: charles.cassius@aphp.fr
• Phone: 630944832

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Evaluating full-body imaging technology for skin disease detection

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• Assessing molecular changes in adults with moderate to severe skin conditions receiving Lutikizumab

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• Collecting samples from people with skin conditions and healthy volunteers

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  Recruiting Innovaderm Research Inc. · Montreal, Quebec · NCT05994976

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.