Identifying targeted treatments for dermatomyositis using advanced genetic analysis
Harnessing single cell RNA sequencing and integrative bioinformatics to identify precision therapeutics for dermatomyositis
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11124607
This study is looking at dermatomyositis, a tough autoimmune condition, to find better and safer treatments by examining blood and skin samples from patients to see how their immune system is affected, and then using that information to repurpose existing medications.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11124607 on ClinicalTrials.gov |
What this research studies
This research focuses on dermatomyositis, a challenging autoimmune condition affecting both children and adults, for which current treatments are limited and often lead to significant side effects. By utilizing single-cell RNA sequencing and advanced bioinformatics, the study aims to uncover specific immune pathways that are disrupted in patients with dermatomyositis. The researchers will then use this information to repurpose existing medications that could effectively target these pathways, potentially leading to safer and more effective treatment options. Patients' blood and skin samples will be analyzed to identify the most promising therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with dermatomyositis, both children and adults.
Not a fit: Patients with dermatomyositis who are already receiving effective treatments or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and safer treatment options for patients with dermatomyositis.
How similar studies have performed: Other research has shown promise in using similar computational approaches to identify new treatments for rare diseases, suggesting potential success for this novel strategy.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NEELY, JESSICA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: NEELY, JESSICA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.