NeoPill to reduce oral bacteria in people with fixed braces

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-arm, pre–post clinical evaluation enrolling about 15–20 adults with fixed orthodontic appliances at the German Medical Institute in Limassol, Cyprus. Baseline oral swabs will be taken from gingival areas and around brackets, followed by a standardized 30-second application of the reusable, battery-operated NeoPill device and immediate post-treatment swab collection. Samples will be cultured in an accredited microbiology lab to quantify aerobic colony-forming units (CFUs) and the primary outcome is the change in CFU counts pre- versus post-application. Participants will also complete a brief questionnaire on usability, comfort, and overall experience to generate preliminary user-experience data.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults aged 18 years or older
* Currently wearing fixed orthodontic appliances
* Able and willing to provide written informed consent
* Able to comply with study procedures during a single study visit

Exclusion Criteria:

* Use of systemic antibiotics within the past 2 weeks
* Presence of active oral infections
* Known immunocompromised status
* Presence of systemic medical conditions that may affect oral bacterial flora

Where it's running

• German Medical Institute
  Limassol, Cyprus Recruiting

Study contacts

• Study coordinator: Georgina Kyriakoudes
• Email: aria@myaria.health
• Phone: +35795112337

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.