Mouth bacteria and artery plaque in people undergoing endarterectomy
Official title: Bacteria in Dental Plaque and Atheroma Plaque
Run by Istanbul Saglik Bilimleri University · NCT07100574 · Data updated 2026-11-12
This research will see if the bacteria found in dental plaque are the same as the bacteria found in artery (atheroma) plaque in people having endarterectomy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Istanbul Saglik Bilimleri University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Istanbul) |
| Status | Recruiting |
| Started | December 10, 2024 |
| Main results expected | December 30, 2025 |
| Study ends | March 30, 2026 |
| Registry record updated | August 3, 2025 |
| Trial ID | NCT07100574 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people scheduled for endarterectomy who are not receiving chemotherapy and have not had prior endarterectomy for the same condition.
✕Probably not a fit
People with active systemic infections, severe heart disease that precludes participation, or those not undergoing endarterectomy are unlikely to benefit from this observational protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Periodontitis can release bacteria or bacterial components into the bloodstream, and prior work has detected oral microbes in atheroma tissue. In this observational study, investigators will collect dental plaque and atheroma plaque samples from patients undergoing endarterectomy and analyze them for specific periodontal pathogens and bacterial markers. Participants will be grouped using the new periodontal classification, and bacterial counts and frequencies will be compared across groups. Demographic and clinical data will be related to microbial findings to explore associations.
Why it matters
Potential benefit: If successful, the findings could clarify whether oral bacteria are linked to artery plaque and help guide prevention or screening efforts that reduce cardiovascular risk.
How similar studies have gone: Previous studies have detected periodontal bacteria in atheroma plaques, so the approach has precedent though causal relationships remain unproven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosed with endarterectomy * Not receiving chemotherapy * Not having received this treatment before Exclusion Criteria: * Having systemic infection * Patients with severe heart disease
Where it's running
-
Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology
Istanbul, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ayşe Toraman
- Email: draysetoraman@gmail.com
- Phone: 05385025422
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Pure green tea mouthwash versus placebo and essential-oil rinses for plaque and gum inflammation
This trial will see if rinsing twice daily with a pure green tea mouthwash reduces dental plaque and gum inflammation in healthy adults compared with placebo and two commercial mouthwashes.
-
Toothpaste for reducing dental plaque and preventing gum problems
This study tests three toothpaste options to see if they reduce plaque and gingivitis in adults with mild gum inflammation.
-
Effect of stannous fluoride toothpaste on gingival health indicators in an experimental gingivitis model
This study tests whether a toothpaste with stannous fluoride can influence gingival crevicular fluid biomarkers and help gingival tissue recover during early gingivitis.
-
Toothpaste that may reduce plaque and gingivitis in Chinese adults
A toothpaste test will be used to see if it reduces plaque and gingivitis more than a regular fluoride toothpaste in Chinese people with localized gingivitis.
-
Safety and effectiveness of an electric flosser with a manual toothbrush for gingivitis and plaque
This study tests whether using an electric interproximal flosser in addition to a manual toothbrush can reduce gingival inflammation and plaque in adults with gingivitis compared with brushing alone.
-
Oil Pulling Mouthwash Reduction in Plaque and Inflammation
A mouthwash-based study will test whether GuruNanda oil pulling rinse can reduce plaque and gum inflammation and bleeding in healthy adults compared with a competitor mouthwash and a water placebo.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.