Clinical trial Recruiting at 1 site Observational Ages 18 to 85

Mouth bacteria and artery plaque in people undergoing endarterectomy

Official title: Bacteria in Dental Plaque and Atheroma Plaque

Run by Istanbul Saglik Bilimleri University · NCT07100574 · Data updated 2026-11-12

This research will see if the bacteria found in dental plaque are the same as the bacteria found in artery (atheroma) plaque in people having endarterectomy.

More Dental Plaque trials

Quick facts

Study typeObservational
Ages18 Years to 85 Years
SexAll
Enrollment60 (estimated)
SponsorIstanbul Saglik Bilimleri University
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Istanbul)
StatusRecruiting
StartedDecember 10, 2024
Main results expectedDecember 30, 2025
Study endsMarch 30, 2026
Registry record updatedAugust 3, 2025
Trial IDNCT07100574 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people scheduled for endarterectomy who are not receiving chemotherapy and have not had prior endarterectomy for the same condition.

Probably not a fit

People with active systemic infections, severe heart disease that precludes participation, or those not undergoing endarterectomy are unlikely to benefit from this observational protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Periodontitis can release bacteria or bacterial components into the bloodstream, and prior work has detected oral microbes in atheroma tissue. In this observational study, investigators will collect dental plaque and atheroma plaque samples from patients undergoing endarterectomy and analyze them for specific periodontal pathogens and bacterial markers. Participants will be grouped using the new periodontal classification, and bacterial counts and frequencies will be compared across groups. Demographic and clinical data will be related to microbial findings to explore associations.

Why it matters

Potential benefit: If successful, the findings could clarify whether oral bacteria are linked to artery plaque and help guide prevention or screening efforts that reduce cardiovascular risk.

How similar studies have gone: Previous studies have detected periodontal bacteria in atheroma plaques, so the approach has precedent though causal relationships remain unproven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Diagnosed with endarterectomy
* Not receiving chemotherapy
* Not having received this treatment before

Exclusion Criteria:

* Having systemic infection
* Patients with severe heart disease

Where it's running

  • Health Sciences University, Hamidiye Faculty of Dentistry, Department of Periodontology
    Istanbul, Turkey (Türkiye)
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.