Comparing probiotic and ethyl lauroyl arginate mouthwashes for lowering cavity‑causing bacteria and plaque in Egyptian schoolchildren
Comparative Evaluation of Probiotic-Based Versus Ethyl Lauroyl Arginate-Containing Mouthwashes on Streptococcus Mutans Counts, Dental Plaque Accumulation, and Salivary pH in a Group of Egyptian School Children: A Randomized Controlled Clinical Trial
This study will test whether a probiotic mouthwash or an ethyl lauroyl arginate mouthwash better lowers Streptococcus mutans, reduces dental plaque, and affects salivary pH in healthy Egyptian children aged 6–12.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 66 (estimated) |
| Ages | 6 Years to 12 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT07356869 on ClinicalTrials.gov |
What this trial studies
Children receive professional dental cleaning and are then assigned to use either a probiotic mouthwash or an ethyl lauroyl arginate (LAE) mouthwash over a defined follow-up period. Investigators measure Streptococcus mutans counts, dental plaque accumulation, and salivary pH at baseline and after treatment to compare effects. The trial is conducted at the Faculty of Dentistry, Al‑Azhar University, with eligibility limited to healthy schoolchildren who have mild to moderate plaque and parental consent. Participants with recent antibiotic use, allergies to mouthwash components, systemic disease, orthodontic appliances, or extensive restorations are excluded.
Who should consider this trial
Good fit: Healthy Egyptian schoolchildren aged 6–12 with mild to moderate dental plaque and parent or caregiver consent are the ideal candidates.
Not a fit: Children who recently used antibiotics, have allergies to mouthwash ingredients, systemic diseases affecting oral health, orthodontic appliances, or large restorations are unlikely to benefit from the interventions tested.
Why it matters
Potential benefit: If successful, the preferred mouthwash could lower levels of cavity‑causing bacteria and plaque and help reduce future caries risk in children.
How similar studies have performed: Prior research has shown that both LAE and some oral probiotics can reduce S. mutans counts and biofilm, though direct head‑to‑head comparisons in children are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy Egyptian schoolchildren aged 6-12 years. * Good general health. * Mild to moderate dental plaque accumulation. * Parental/caregiver willingness to provide consent Exclusion Criteria: * Antibiotic or antimicrobial use within the last month. * Allergies to the mouthwash components. * Systemic diseases affecting oral health. * Orthodontic appliances or extensive dental restorations.
Where this trial is running
Cairo
- Al-Azhar University (Faculty of Dentistry) — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Mohamed O Abdelrazik, MBBCH
- Email: mohamedghitany96@gmail.com
- Phone: 00201017005990
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.