American-style low-fat, high-fiber diet to reduce gut inflammation in ulcerative colitis
Official title: Targeting gut inflammation through diet: a tailored American diet for patients with ulcerative colitis
Funded at University of Miami School of Medicine · NIH-11180220 · Data updated 2026-11-12
A low-fat, high-fiber American-style diet with a balanced n-6:n-3 fat ratio to help adults with mild to moderate ulcerative colitis reach remission.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $333,863 |
| NIH project number | 5R01DK140964-02 |
| Project ID | NIH-11180220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in the United States with mild to moderate ulcerative colitis who can follow a dietary program and attend clinic visits.
✕Less likely to help
People with severe or fulminant ulcerative colitis, those needing immediate surgery, or those unable to adhere to the diet may not benefit.
What this research studies
You will follow a personalized American-style low-fat (<3:1 n-6:n-3), high-fiber diet built around foods you prefer. The study compares this tailored diet to a typical Western diet over an eight-week period to see who reaches disease remission. Researchers will collect stool samples to study the microbiome and blood samples to measure polyunsaturated fatty acids before and after the diet. The team will examine whether your baseline microbiome or blood PUFA levels help predict who benefits from the diet.
Why it matters
Potential benefit: If successful, this could provide a personalized, food-based way to help people with ulcerative colitis achieve remission and lower inflammation.
How similar studies have gone: Small pilot studies and preliminary data suggest low-fat, higher-fiber diets and PUFA-informed approaches can lower inflammation, but larger randomized trials are limited.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Damas, Oriana Mazorra — University of Miami School of Medicine
- Study coordinator: Damas, Oriana Mazorra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.