Tailored American diet to reduce gut inflammation in ulcerative colitis
Official title: Targeting gut inflammation through diet: a tailored American diet for patients with ulcerative colitis
Funded at University of Miami School of Medicine · NIH-11391291 · Data updated 2026-11-12
A doctor-led study will test whether an American-tailored, lower-fat, higher-fiber diet helps people with ulcerative colitis achieve remission.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $333,863 |
| NIH project number | 5R01DK140964-03 |
| Project ID | NIH-11391291 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with mild to moderate ulcerative colitis who are interested in a dietary approach to disease management.
✕Less likely to help
People unable to adhere to dietary changes or with severe disease may not benefit and may have different treatment needs.
What this research studies
If you have ulcerative colitis, this study will test a personalized, American-friendly diet designed to lower inflammation and improve adherence. Participants will follow a low-fat (n-6 to n-3 ratio under 3:1) and higher-fiber diet while researchers monitor symptoms, stool markers, and blood fats. The study also looks at whether your gut microbiome and blood PUFA levels influence how well the diet works for you. This could lead to dietary guidelines that fit real American eating patterns and personal food preferences. Enrollment and follow-up are designed to assess whether the diet helps achieve disease remission by about week 8.
Why it matters
Potential benefit: If successful, participants may experience reduced disease activity and better symptom control through a practical dietary plan.
How similar studies have gone: Preliminary data suggest diet can influence UC inflammation, but this specific American-tailored diet needs confirmation in a targeted trial.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Damas, Oriana Mazorra — University of Miami School of Medicine
- Study coordinator: Damas, Oriana Mazorra
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.