IMYX-3 treatment for ulcerative colitis

Who could benefit from this research

What this research studies

This project targets ulcerative colitis by modulating intestinal cells and immune responses to reduce inflammation and tissue damage. Researchers are exploring the role of RAB27A in colon tissue and how altering its activity might improve disease symptoms in animal models and human samples. The study will involve basic lab work to understand how IMYX-3 affects immune cells and epithelial cells in the gut, with the goal of translating findings toward new treatment options for patients. The grant supports preclinical development and early testing to establish a foundation for future clinical studies.

Why it matters

Where this research is happening

• Immunyx Pharma USA INC.
  New York, United States Active

Researchers

• Principal investigator: Eng, Christina — Immunyx Pharma USA INC.
• Study coordinator: Eng, Christina

Related research

Other NIH-funded projects on the same topics.

• Outpatient pathway for severe ulcerative colitis in the right care setting

  This study tests a safe, outpatient approach using an oral therapy and remote monitoring for people with acute severe ulcerative colitis to avoid hospitalization.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11438442

• Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis

  A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.

  NIH research University of Puerto Rico Med Sciences · San Juan, United States · NIH-11424600

• Autoantibodies and ulcerative colitis: how avb6 antibodies may drive disease

  This NIH grant aims to understand how antibodies against a gut cell protein (αvβ6) may actively contribute to ulcerative colitis and what that means for future treatments.

  NIH research Benaroya Research Inst at Virginia Mason · Seattle, United States · NIH-11412898

• Selenium supplementation to help moderate-severe ulcerative colitis flare-ups

  This grant tests whether giving selenium can help people with moderate to severe ulcerative colitis reduce flares and improve symptoms.

  NIH research Northwestern University · Chicago, United States · NIH-11412675

• Development of TP-317 for Ulcerative Colitis

  A new therapy approach for ulcerative colitis aims to repair the intestinal lining and restore immune balance in people with UC, addressing a need for patients who don’t fully respond to current treatments.

  NIH research Thetis Pharmaceuticals, LLC · Deep River, United States · NIH-11406737

• Sulfite and mitochondrial function in pediatric ulcerative colitis

  A child-focused project will study how sulfites in the diet affect mitochondria and gut lining cells in kids with ulcerative colitis.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11398638

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.