Understanding how inflammation contributes to colorectal cancer development
Dissecting the Myeloid-Th17 axis in the pathogenesis of Colitis-associated Colorectal Cancer
['FUNDING_OTHER'] · UNIVERSITY OF ALABAMA AT BIRMINGHAM · NIH-11231961
This study is looking at how long-lasting inflammation in the intestines might lead to colorectal cancer, and it's for people who want to understand more about the disease and how to improve treatments by exploring the immune system's role in tumor growth.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ALABAMA AT BIRMINGHAM (nih funded) |
| Locations | 1 site (BIRMINGHAM, UNITED STATES) |
| Trial ID | NIH-11231961 on ClinicalTrials.gov |
What this research studies
This research investigates the role of chronic intestinal inflammation in the development of colorectal cancer, particularly focusing on the myeloid-Th17 axis. By using a specific model of inflammation-driven colon cancer, the researchers aim to identify the cellular and molecular mechanisms that promote tumor growth. The study will analyze the tumor microenvironment, including the types of immune cells present and their functions, to uncover potential therapeutic targets for improving treatment outcomes in colorectal cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of chronic intestinal inflammation or those at risk for colitis-associated colorectal cancer.
Not a fit: Patients without chronic intestinal inflammation or those with other types of cancer unrelated to colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better target inflammation-related mechanisms in colorectal cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
BIRMINGHAM, UNITED STATES
- UNIVERSITY OF ALABAMA AT BIRMINGHAM — BIRMINGHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHADHA, AWALPREET SINGH — UNIVERSITY OF ALABAMA AT BIRMINGHAM
- Study coordinator: CHADHA, AWALPREET SINGH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.