Understanding how inflammation contributes to colorectal cancer development
Official title: Dissecting the Myeloid-Th17 axis in the pathogenesis of Colitis-associated Colorectal Cancer
Funded at University of Alabama at Birmingham · NIH-11231961 · Data updated 2026-11-12
This study is looking at how long-lasting inflammation in the intestines might lead to colorectal cancer, and it's for people who want to understand more about the disease and how to improve treatments by exploring the immune system's role in tumor growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | February 3, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $248,936 |
| NIH project number | 4R00CA277554-03 |
| Project ID | NIH-11231961 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of chronic intestinal inflammation or those at risk for colitis-associated colorectal cancer.
✕Less likely to help
Patients without chronic intestinal inflammation or those with other types of cancer unrelated to colorectal cancer may not benefit from this research.
What this research studies
This research investigates the role of chronic intestinal inflammation in the development of colorectal cancer, particularly focusing on the myeloid-Th17 axis. By using a specific model of inflammation-driven colon cancer, the researchers aim to identify the cellular and molecular mechanisms that promote tumor growth. The study will analyze the tumor microenvironment, including the types of immune cells present and their functions, to uncover potential therapeutic targets for improving treatment outcomes in colorectal cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that better target inflammation-related mechanisms in colorectal cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Chadha, Awalpreet Singh — University of Alabama at Birmingham
- Study coordinator: Chadha, Awalpreet Singh
Related research
Other NIH-funded projects on the same topics.
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How immune cells and Th17 inflammation drive colitis-related colon cancer
This project looks at how certain immune cells and ongoing gut inflammation help cause colon cancer in people with long-term colitis.
-
Gut bacteria and colorectal cancer risk in people with ulcerative colitis
Researchers are looking at whether certain gut bacteria help protect against or promote colorectal cancer in people who have ulcerative colitis.
-
Best ages for colonoscopy to catch colorectal cancer in people with colitis
This project uses math, genetic information, and tissue data to find the right ages for colonoscopies so people with inflammatory bowel disease can catch colorectal cancer earlier while avoiding unnecessary procedures.
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Understanding how gut bacteria influence colorectal cancer in patients with ulcerative colitis
This study is looking at how the bacteria in your gut might influence the risk of developing colorectal cancer if you have ulcerative colitis, and it aims to find out which types of bacteria could help protect you or possibly increase that risk.
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Improving cancer screening for Veterans with inflammatory bowel disease
This study is looking to improve how we check for colorectal cancer in Veterans with inflammatory bowel disease (IBD) by finding out the best times for screenings based on individual risk, so that everyone gets the right care without unnecessary tests.
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Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.