Understanding how deep inflammation in ulcerative colitis affects patient outcomes
Characterizing the transmural nature of ulcerative colitis and its associated disease-related outcomes using intestinal ultrasound: a paradigm shift in treatment targets
['FUNDING_OTHER'] · UNIVERSITY OF CHICAGO · NIH-11138143
This study is looking at how changes in the deeper layers of the bowel affect the health and quality of life of people with ulcerative colitis, using ultrasound to find out what might help improve their symptoms and overall care.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11138143 on ClinicalTrials.gov |
What this research studies
This research investigates the deeper structural changes in the bowel wall of patients with ulcerative colitis (UC) and how these changes relate to their overall health and quality of life. By using intestinal ultrasound, the study aims to identify predictors of these changes and their impact on disease outcomes. The goal is to shift the focus from just healing the surface of the bowel to understanding and treating the deeper layers that may contribute to ongoing symptoms and complications. This approach could lead to new treatment targets and improve patient care.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with ulcerative colitis, whether they are experiencing active symptoms or are in remission.
Not a fit: Patients with ulcerative colitis who have already undergone extensive surgical interventions or those with other unrelated gastrointestinal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ulcerative colitis by addressing the underlying causes of disease-related complications.
How similar studies have performed: While the approach of using intestinal ultrasound to assess deeper bowel changes is innovative, similar studies have shown promise in understanding inflammatory bowel diseases, suggesting potential for success.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CLEVELAND, NOA KRUGLIAK — UNIVERSITY OF CHICAGO
- Study coordinator: CLEVELAND, NOA KRUGLIAK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.