Crohn's-like inflammation in the ileal pouch after colon removal for ulcerative colitis
Official title: Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11287861 · Data updated 2026-11-12
This project looks for genetic, tissue, microbiome, and metabolite patterns linked to Crohn’s-like inflammation in people with ulcerative colitis who had their colon removed and an ileal pouch created.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $190,904 |
| NIH project number | 5K23DK127241-05 |
| Project ID | NIH-11287861 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are people with medically refractory ulcerative colitis who underwent restorative proctocolectomy with IPAA and either have developed or are at risk of developing Crohn’s-like pouch inflammation, typically seen at the Mount Sinai IBD program or affiliated clinics.
✕Less likely to help
People without ulcerative colitis, those who have not had an IPAA, or people with unrelated gastrointestinal conditions are unlikely to receive direct benefit from this project.
What this research studies
If you had restorative proctocolectomy with an ileal pouch-anal anastomosis (IPAA), researchers will collect clinical data and biospecimens such as blood, stool, and ileal tissue to study why some people develop Crohn’s Disease-like pouch inflammation (CDLPI). They will sequence bacteria (16S rRNA), analyze the ileal transcriptome, profile metabolites, and examine genetic variants to find patterns tied to pouch inflammation over time. The study uses a longitudinal cohort approach comparing people who develop CDLPI with those who do not and applies integrated multi-omics analysis to identify risk features. Participation could involve clinic visits, sample collection, and access to your medical records for research purposes.
Why it matters
Potential benefit: If successful, this work could help predict who is at higher risk for Crohn’s-like pouch inflammation and guide more personalized prevention or treatment strategies.
How similar studies have gone: Microbiome and multi-omics studies in inflammatory bowel disease have shown promising leads, but applying integrated genetic, transcriptomic, microbiome, and metabolomic profiling specifically to post-IPAA Crohn’s-like pouch inflammation is relatively novel.
Where this research is happening
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Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Kayal, Maia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kayal, Maia
Related research
Other NIH-funded projects on the same topics.
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Understanding pouch inflammation in ulcerative colitis patients after surgery
This study is looking at how certain biological changes happen in people with ulcerative colitis after they have a surgery called restorative proctocolectomy, especially for those who might develop inflammation similar to Crohn's disease, to help find better ways to treat and monitor their condition.
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Site-specific gene-microbial interactions in children with Crohn’s disease
A child-focused study explores how genes and gut microbes interact in very young children with Crohn’s disease to understand why the disease starts and how it might be treated.
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Ultrasound markers to measure Crohn’s disease activity
A Mayo Clinic team is testing new 3D ultrasound methods to reliably track inflammation and scarring in Crohn’s disease using safe, affordable imaging that could replace more costly scans.
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Outpatient pathway for severe ulcerative colitis in the right care setting
This study tests a safe, outpatient approach using an oral therapy and remote monitoring for people with acute severe ulcerative colitis to avoid hospitalization.
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Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis
A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.
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IMYX-3 treatment for ulcerative colitis
A new therapy approach called IMYX-3 aims to help adults with moderate to severe ulcerative colitis who have not responded well to current treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.