Crohn's-like inflammation in the ileal pouch after colon removal for ulcerative colitis
Characterizing the Biologic Evolution of Crohn's Disease Like Pouch Inflammation in Ulcerative Colitis Patients After Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis
This project looks for genetic, tissue, microbiome, and metabolite patterns linked to Crohn’s-like inflammation in people with ulcerative colitis who had their colon removed and an ileal pouch created.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11287861 on NIH RePORTER |
What this research studies
If you had restorative proctocolectomy with an ileal pouch-anal anastomosis (IPAA), researchers will collect clinical data and biospecimens such as blood, stool, and ileal tissue to study why some people develop Crohn’s Disease-like pouch inflammation (CDLPI). They will sequence bacteria (16S rRNA), analyze the ileal transcriptome, profile metabolites, and examine genetic variants to find patterns tied to pouch inflammation over time. The study uses a longitudinal cohort approach comparing people who develop CDLPI with those who do not and applies integrated multi-omics analysis to identify risk features. Participation could involve clinic visits, sample collection, and access to your medical records for research purposes.
Who could benefit from this research
Good fit: Ideal candidates are people with medically refractory ulcerative colitis who underwent restorative proctocolectomy with IPAA and either have developed or are at risk of developing Crohn’s-like pouch inflammation, typically seen at the Mount Sinai IBD program or affiliated clinics.
Not a fit: People without ulcerative colitis, those who have not had an IPAA, or people with unrelated gastrointestinal conditions are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help predict who is at higher risk for Crohn’s-like pouch inflammation and guide more personalized prevention or treatment strategies.
How similar studies have performed: Microbiome and multi-omics studies in inflammatory bowel disease have shown promising leads, but applying integrated genetic, transcriptomic, microbiome, and metabolomic profiling specifically to post-IPAA Crohn’s-like pouch inflammation is relatively novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Kayal, Maia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kayal, Maia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.