Diagnose high-grade ovarian cancer precursors and hidden tumors
Official title: Project 1: Diagnose high-grade ovarian serous carcinoma precursors and occult tumors
Funded at Johns Hopkins University · NIH-11399029 · Data updated 2026-11-12
This grant aims to improve early detection of ovarian cancer precursors and occult tumors by analyzing cells collected from the fallopian tubes and surrounding areas in high-risk women.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 18, 2018 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $655,318 |
| NIH project number | 5P50CA228991-08 |
| Project ID | NIH-11399029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals at high risk for ovarian cancer who are undergoing risk-reducing salpingo-oophorectomy and consent to tissue sampling for analysis.
✕Less likely to help
People not at high risk or not undergoing the described procedures would not directly benefit from this specific study.
What this research studies
If you’re at high risk for ovarian cancer, this project would use new lab tests on cells brushed from the fallopian tubes and nearby areas to detect early tumor changes that current methods might miss. By applying advanced DNA and methylation analyses, researchers hope to identify STIC lesions and incipient HGSC more reliably after risk-reducing surgeries. The work is designed to be conducted on tissue samples from Johns Hopkins, helping doctors diagnose and potentially catch cancer earlier. This could lead to better monitoring and personalized care for people with high risk due to family history or other factors.
Why it matters
Potential benefit: If successful, it could enable earlier and more accurate detection of ovarian cancer precursors, potentially improving outcomes and guiding prevention strategies.
How similar studies have gone: Previous approaches have shown promise in detecting early ovarian cancer markers, but this project combines novel aneuploidy and methylation markers to improve accuracy.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Papadopoulos, Nickolas — Johns Hopkins University
- Study coordinator: Papadopoulos, Nickolas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.