Spatial immune patterns in colorectal adenoma-carcinoma progression
Official title: Spatial Immunopathological Epidemiology of Colorectal Adenoma-Carcinoma Spectrum
Funded at Brigham and Women's Hospital · NIH-11446834 · Data updated 2026-11-12
A long-term study looking at how immune cells in the colon relate to the development of colorectal precancers and cancers in adult participants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2020 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,001,628 |
| NIH project number | 2R01CA248857-08 |
| Project ID | NIH-11446834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in the Health Professionals Follow-up Study and Nurses’ Health Study cohorts who provide long-term lifestyle and tissue data.
✕Less likely to help
People not enrolled in these cohorts or without available long-term exposure and tumor profiling data may not directly benefit.
What this research studies
This project follows health professionals and nurses over many years to map immune cells in the colon as people develop or avoid colorectal tumors. It uses tumor and tissue samples, along with lifestyle data, to understand how factors like aspirin, alcohol, coffee, and exercise may influence cancer risk over time. By combining long-term exposure histories with detailed immune profiling, it aims to reveal how early immune changes relate to later colorectal disease and the impact of daily habits.
Why it matters
Potential benefit: If successful, it could lead to personalized prevention strategies and timing of interventions to reduce colorectal cancer risk.
How similar studies have gone: Previous studies show that immune patterns and lifestyle factors influence colorectal cancer risk, but integrating long-term exposure with spatial immune profiling is still emerging.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Ogino, Shuji — Brigham and Women's Hospital
- Study coordinator: Ogino, Shuji
Related research
Other NIH-funded projects on the same topics.
-
Novel idea: Epstein-Barr virus and eye cancer in people living with HIV in Zimbabwe
A study explores whether Epstein-Barr virus could cause a type of eye cancer in people living with HIV in Zimbabwe.
-
Glutamine and macrophage behavior in liver cancer
A funded project at a medical university aims to understand how the liver’s immune cells interact with a specific type of liver cancer by looking at metabolism, especially glutamine and ammonia.
-
Understanding bladder cancer biology to find new biomarkers and therapies
A study at Tuskegee University will look at the molecules inside high-grade bladder cancer to discover new markers and potential treatment targets.
-
Oral cancer recurrence predictor using tumor microbes and gene activity
This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.
-
Understanding how bladder cancer starts in Veterans exposed to carcinogens and the role of PPAR-g in early bladder cancer
A research team is studying how bladder cancer begins and progresses in Veterans exposed to carcinogens, focusing on the PPAR-γ protein and early precancerous changes.
-
Adding PSMA PET/CT imaging to liver cancer care for veterans
This project tests a new PET imaging approach to help diagnose and guide treatment for liver cancer in veterans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.