Understanding how bladder cancer starts in Veterans exposed to carcinogens and the role of PPAR-g in early bladder cancer
Official title: BCCMA: Basic and Translational Mechanisms of Cancer Initiation of the Urothelium in Veterans Exposed to Carcinogens: Role of PPARg in theFormation and Progression of Carcinoma in situ of the Bladder
Funded at VA Medical Center · NIH-11575172 · Data updated 2026-11-12
A research team is studying how bladder cancer begins and progresses in Veterans exposed to carcinogens, focusing on the PPAR-γ protein and early precancerous changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Medical Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| NIH project number | 5I01BX005602-05 |
| Project ID | NIH-11575172 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans with exposure to bladder carcinogens and individuals at risk of CIS or bladder cancer may be eligible for related studies or future trials.
✕Less likely to help
Patients not exposed to bladder carcinogens or not at risk of CIS may have no direct benefit from this specific research.
What this research studies
This project investigates how carcinoma in situ of the bladder forms and progresses, using a combination of basic biology and translational approaches. The team will explore genomic, epigenetic, and transcriptional factors, with a special focus on PPAR-γ and its regulatory networks. The work involves collaboration between VA clinicians and researchers across multiple centers to connect laboratory findings with potential clinical applications for early detection and prevention. The study uses human-derived samples and model systems to uncover mechanisms that could inform future therapies or monitoring strategies for at-risk Veterans.
Why it matters
Potential benefit: If successful, the findings could improve early detection and prevention strategies for bladder cancer in Veterans exposed to harmful carcinogens.
How similar studies have gone: Previous work has shown that epigenetic and transcriptional regulation play key roles in bladder cancer initiation, supporting the potential of this approach.
Where this research is happening
-
VA Medical Center
New York, United States Active
Researchers
- Principal investigator: Wu, Xue-Ru — VA Medical Center
- Study coordinator: Wu, Xue-Ru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.