Condition

Disorders of Consciousness Due to Severe Brain Injury clinical trials and research

• 9Clinical trials
• 1New in 30 days
• 6Countries

Newest Disorders of Consciousness Due to Severe Brain Injury clinical trials

All recruiting trials (9)

• Caregivers and patients with severe brain injury: using the SAFE scale to monitor behavior together

  A caregiver-friendly tool called the SAFE scale is tested to see if involving family members in daily observations helps care teams track DoC patients more consistently.

  Recruiting Fondazione Don Carlo Gnocchi ETS · Florence · NCT07912372

• Dual-Site Ear Nerve Stimulation for Severe Brain Injury-Related Coma

  This study tests a gentle, non-invasive stimulation on the left ear to try to help some people in coma due to severe traumatic brain injury regain awareness.

  Recruiting Stony Brook University · Stony Brook, New York · NCT07719595

• Focusing ultrasound to the central thalamus to help people with disorders of consciousness

  This study tests whether two sessions of low-intensity focused ultrasound can safely help people with severe brain injuries see if they become more awake or responsive.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT07694258

• Transcutaneous Electrical Acupoint Stimulation at Hand Jing-Well Points for Disorders of Consciousness

  We test a noninvasive electrical stimulation at hand points to see if it can help people who have altered consciousness after severe brain injury.

  Recruiting Phase 2/3 Xijing Hospital · Xi'an, Shaanxi · NCT07535593

• Can a bedside brain scan (fNIRS) detect activity in healthy people and in people with disorders of consciousness

  This observational study tests whether functional near-infrared spectroscopy (fNIRS) can measure brain activity at the bedside in healthy adults and in patients with disorders of consciousness in the Neuro-ICU.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT07485361

• Checking consciousness using the CRS-R and a shorter SECONDs checklist

  This tests whether a shorter checklist called SECONDs can help doctors quickly and accurately determine consciousness level in people recovering from severe brain injury.

  Recruiting BDH-Klinik Hessisch Oldendorf · Hessisch Oldendorf, Lower Saxony · NCT07456020

• Focused ultrasound to promote recovery after severe brain injury.

  This test uses low-intensity focused ultrasound on adults with disorders of consciousness after severe brain injury to see if it improves responsiveness and brain activity.

  Recruiting at 2 sites Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07277309

• Using smells to help predict recovery in comatose or unresponsive ICU patients

  This will test whether brief smell challenges and a patient's 'sniff' response can help predict neurological and functional status three months later for adults who remain unresponsive after stopping sedation in the neuro-ICU.

  Recruiting Centre Hospitalier St Anne · Paris, GHU Psychiatrie Et Neurosciences · NCT07127224

• Targeted thalamic ultrasound to help recovery after severe brain injury

  This will try focused ultrasound to the thalamus to see if it helps people with a prolonged disorder of consciousness after traumatic brain injury.

  Recruiting at 3 sites University of California, Los Angeles · Los Angeles, California and 3 other locations · NCT06939348

Related topics

Quick answers

How many Disorders of Consciousness Due to Severe Brain Injury clinical trials are recruiting right now?

9, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (4 trials), Germany (1 trial), Canada (1 trial), France (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →