Condition

Metastatic HER2-Negative Breast Carcinoma clinical trials and research

• 7Clinical trials
• 3Countries

Newest Metastatic HER2-Negative Breast Carcinoma clinical trials

All recruiting trials (7)

• STEMVAC vaccine with hormone therapy plus CDK4/6 inhibitor or capecitabine for metastatic HR-positive, HER2-negative breast cancer

  This trial tests whether adding the STEMVAC vaccine to standard hormone therapy with a CDK4/6 drug, or to capecitabine chemotherapy, helps people with metastatic hormone receptor–positive, HER2‑negative breast cancer.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT07112053

• Adaptive capecitabine therapy for metastatic ER-positive, HER2-negative breast cancer

  This trial will try using capecitabine with dose changes based on tumor imaging and blood markers in adults with metastatic ER-positive, HER2-negative breast cancer.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06525766

• Using imaging to predict response to abemaciclib in advanced breast cancer

  This study is testing if special imaging can help doctors figure out which patients with advanced breast cancer will respond best to a new treatment combining abemaciclib and hormone therapy.

  Recruiting at 3 sites Phase 2 University of Washington · St Louis, Missouri and 2 other locations · NCT06179303

• Using blood tests to guide chemotherapy changes in metastatic breast cancer

  This study is testing if using blood tests to track cancer DNA can help doctors change chemotherapy treatments faster for people with metastatic triple-negative breast cancer.

  Recruiting Phase 2 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT05770531

• Targeted therapy for advanced solid tumors based on genetic testing

  This study is testing whether matching patients with advanced solid tumors to specific treatments based on their genetic makeup can improve their outcomes when standard options have failed.

  Recruiting at 437 sites Phase 2 National Cancer Institute (NCI) · Birmingham, Alabama and 483 other locations · NCT05564377

• Combining UTD1 and Capecitabine for HER2-negative Breast Cancer with Brain Metastases

  This study is testing if a new treatment combining UTD1 and Capecitabine can help people with HER2-negative breast cancer that has spread to the brain.

  Recruiting Phase 1/2 Hunan Cancer Hospital · Changsha · NCT05535413

• Personalized vaccine treatment for advanced melanoma, breast cancer, and lung cancer

  This study is testing a personalized vaccine combined with a treatment called nivolumab to see if it can help people with advanced melanoma, breast cancer, or lung cancer fight their tumors better.

  Recruiting Phase 1 Fred Hutchinson Cancer Center · Seattle, Washington · NCT05098210

Related topics

Quick answers

How many Metastatic HER2-Negative Breast Carcinoma clinical trials are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (6 trials), China (1 trial), Puerto Rico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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