Condition

Anatomic Stage II Breast Cancer AJCC v8 clinical trials and research

• 38Clinical trials
• 4Countries

Newest Anatomic Stage II Breast Cancer AJCC v8 clinical trials

All recruiting trials (38)

• Blended e-Health Program to Help Women with Breast or Gynecologic Cancer Manage Fear of Cancer Progression

  This trial tests a blended online and group program to see if it helps women with breast or gynecologic cancer feel less fear that their cancer could grow or spread.

  Recruiting at 11 sites City of Hope Medical Center · Arcadia, California and 10 other locations · NCT07741968

• Navigation program to boost survivorship support participation for non-metastatic breast cancer survivors

  This program tests whether a patient navigation service helps non-metastatic breast cancer survivors use survivorship support services more often.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07699991

• Personalized Exercise Plan for Breast Cancer Survivors on Chemotherapy

  This trial tests whether adding a guided exercise program to a healthy-lifestyle education plan helps breast cancer patients undergoing chemotherapy maintain fitness, heart health, and quality of life.

  Recruiting at 3 sites Wake Forest University Health Sciences · Winston-Salem, North Carolina and 3 other locations · NCT07474090

• Goserelin Injections: Is Upper-Gluteal Dosing as Good as Abdominal Dosing for OFS in Localized and Locally Advanced HR+ Breast Cancer

  This phase 2 trial tests whether giving goserelin acetate injections in the upper gluteal region works as well as abdominal injections for suppressing ovarian function in premenopausal women with localized or locally advanced hormone receptor–positive breast cancer.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT07460752

• Resistant potato starch to reduce joint and muscle symptoms in people starting aromatase inhibitors for early-stage or high-risk breast cancer

  This phase II trial will test whether taking resistant potato starch can reduce joint pain and stiffness in people with stage 0–III or high-risk breast cancer who are starting aromatase inhibitor therapy.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07443943

• Adjunct Therapy De-escalation in Early HER2+ and TNBC After Neoadjuvant Response

  This phase 2 trial tests stopping certain post-surgery immunotherapy and targeted therapies early in people with early HER2+ or triple-negative breast cancer who have no detectable cancer DNA after neoadjuvant treatment and surgery.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT07407920

• Hormone therapy with ribociclib vs chemotherapy followed by hormone therapy with ribociclib for high-risk stage breast cancer

  This trial tests whether hormone therapy with ribociclib works as well as chemotherapy followed by hormone therapy with ribociclib for patients with high-stage, estrogen receptor-positive, HER2-negative breast cancer at low risk of recurrence.

  Recruiting at 257 sites Phase 3 National Cancer Institute (NCI) · Jonesboro, Arkansas and 257 other locations · NCT07391774

• Sleep Changes and Biomarkers After Breast Cancer Treatment

  This project will see how sleep patterns and stress-related biological markers change from treatment through survivorship in people with stage I–III hormone receptor–positive breast cancer.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07341503

• Imlunestrant and Abemaciclib for ER+ Breast Cancer with Minimal Residual Disease

  This Phase 2 trial tests whether taking imlunestrant and abemaciclib together can help people with ER-positive breast cancer who still have detectable cancer after initial treatment.

  Recruiting Phase 2 Jonsson Comprehensive Cancer Center · Los Angeles, California · NCT07191717

• Leuprolide versus goserelin to stop ovarian estrogen production in pre- or peri-menopausal women with breast cancer

  This study tests whether two doses of leuprolide or goserelin better stops the ovaries from making estrogen in pre- or peri-menopausal women with breast cancer.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07158021

• 5-strain probiotic to prevent bone loss during aromatase inhibitor therapy

  This trial will try a 5-strain probiotic called WBF-038 to see if it prevents bone loss in people with early-stage hormone receptor–positive breast cancer who are starting aromatase inhibitor therapy.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07044310

• Darolutamide alone or with standard pre-surgery therapy for stage II–IIIA AR‑positive triple‑negative breast cancer.

  This trial will test whether adding darolutamide to standard pre-surgery chemo‑immunotherapy helps people with stage II–IIIA androgen receptor–positive triple‑negative breast cancer.

  Recruiting Phase 2 Vanderbilt-Ingram Cancer Center · Nashville, Tennessee · NCT07016399

• Optimized ultrasound twinkling marker to image axillary lymph nodes in clinically node-positive breast cancer

  This trial tests an improved ultrasound twinkling marker to help doctors reliably see cancer-containing lymph nodes by ultrasound in people with biopsy-proven node-positive breast cancer.

  Recruiting Phase 1 Mayo Clinic · Rochester, Minnesota · NCT06999798

• Ultra‑short whole-breast radiation with lumpectomy cavity boost for stage I–III breast cancer

  This trial will test whether a very short course of whole‑breast radiation with a boost to the lumpectomy cavity works well and is safe for women age 40 and older with stage I–III breast cancer who had breast‑conserving surgery.

  Recruiting at 6 sites Phase 2 City of Hope Medical Center · Arcadia, California and 6 other locations · NCT06954831

• 6 months versus 12 months of HER2-targeted therapy after a complete response to preoperative chemo for early HER2+ breast cancer

  This tests whether 6 months of HER2-targeted therapy works as well as 12 months for people with early HER2+ breast cancer who had a pathologic complete response after preoperative chemotherapy with trastuzumab.

  Recruiting at 604 sites Phase 3 Alliance for Clinical Trials in Oncology · Phoenix, Arizona and 701 other locations · NCT06876714

• Using metformin to treat insulin resistance in women with early-stage breast cancer after chemotherapy

  This study is testing if metformin can help women with early-stage breast cancer who have finished chemotherapy and are struggling with insulin resistance to improve their health.

  Recruiting Phase 3 City of Hope Medical Center · Duarte, California and 2 other locations · NCT06763328

• Hypofractionated radiotherapy for non-metastatic breast cancer treatment

  This study is testing if giving a shorter course of radiation therapy before or after surgery can help women with non-metastatic breast cancer while causing fewer severe side effects.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06635980

• Nutrition intervention for women with triple negative breast cancer

  This study is testing if following a healthy eating plan called the MIND diet can help women with triple negative breast cancer feel better mentally and physically while they are undergoing chemotherapy.

  Recruiting at 2 sites Ohio State University Comprehensive Cancer Center · New Haven, Connecticut and 1 other locations · NCT06582615

• Using acupuncture and acupressure to reduce joint pain in Black women with early-stage breast cancer

  This study is testing whether acupuncture and virtual acupressure can help reduce joint pain for Black women with early-stage breast cancer who are taking hormone therapy.

  Recruiting at 4 sites Emory University · Atlanta, Georgia and 3 other locations · NCT06534125

• Improving skin quality and self-esteem in breast cancer survivors on hormone therapy

  This study is testing how hormone therapy affects skin quality and self-esteem in breast cancer survivors, while also offering skincare advice to see if it helps them feel better about themselves.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06401889

• Measuring a biomarker for breast cancer treatment effectiveness

  This study is testing if measuring a specific biomarker can help doctors understand how well hormone treatments are working for people with advanced breast cancer.

  Recruiting Mayo Clinic · Jacksonville, Florida · NCT06388122

• Personalized tumor vaccine with checkpoint inhibitors for triple negative breast cancer

  This phase I trial will test whether a personalized tumor membrane vesicle (TMV) vaccine, given alone or with pembrolizumab or ipilimumab, can boost immune response and help control disease in adults with triple negative breast cancer.

  Recruiting at 4 sites Phase 1 Emory University · Atlanta, Georgia and 3 other locations · NCT06324240

• Using fisetin and exercise to prevent frailty in breast cancer survivors

  This study is testing whether taking fisetin, a natural supplement, along with exercise can help prevent frailty in postmenopausal breast cancer survivors who have had chemotherapy.

  Recruiting at 6 sites Phase 2 Jonsson Comprehensive Cancer Center · Alhambra, California and 5 other locations · NCT06113016

• Combining an immunotherapy drug with standard chemotherapy for advanced breast cancer

  This study is testing if adding an immunotherapy drug called durvalumab to standard chemotherapy can help people with advanced hormone receptor-positive, HER2-negative breast cancer live longer and feel better.

  Recruiting at 552 sites Phase 3 National Cancer Institute (NCI) · Birmingham, Alabama and 564 other locations · NCT06058377

• Dose-reduced chemotherapy for older women with early-stage HER2 negative breast cancer

  This study is testing if a lower dose of chemotherapy can help older women with early-stage HER2 negative breast cancer feel better during treatment compared to the standard dose.

  Recruiting at 3 sites Phase 2 City of Hope Medical Center · Duarte, California and 2 other locations · NCT06042569

• Weight loss program for Latina breast cancer survivors

  This study tests a weight loss program designed for Latina breast cancer survivors to see if it helps them lose weight and improve their health through online education and support.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT05930483

• Shorter chemotherapy and immunotherapy for early-stage triple negative breast cancer

  This study is testing whether a shorter treatment plan of chemotherapy and immunotherapy without certain strong drugs can help people with early-stage triple negative breast cancer do better than the usual longer treatment.

  Recruiting at 923 sites Phase 3 SWOG Cancer Research Network · Birmingham, Alabama and 962 other locations · NCT05929768

• Online nutrition education to ease chemotherapy side effects for breast cancer patients

  A online nutrition program is tested alongside standard care to see if it reduces chemotherapy-related side effects in women with stage I–III breast cancer.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT05874297

• Comparing pembrolizumab to observation for early-stage triple-negative breast cancer after chemotherapy

  This study tests whether a drug called pembrolizumab can help prevent the return of early-stage triple-negative breast cancer after chemotherapy, compared to just keeping an eye on patients without extra treatment.

  Recruiting at 797 sites Phase 3 Alliance for Clinical Trials in Oncology · Birmingham, Alabama and 845 other locations · NCT05812807

• Biorepository for breast cancer survivors

  This study is collecting blood samples and health information from women who have survived early to moderate stage breast cancer to help with future research on survivorship.

  Recruiting University of Southern California · Los Angeles, California · NCT05786664

• Biobehavioral stress reduction for patients with triple negative breast cancer

  This study is testing a stress reduction program for people who have just been diagnosed with triple negative breast cancer to see if it helps them feel better and cope with their situation.

  Recruiting at 2 sites Ohio State University Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT05677802

• Using fisetin to enhance physical function in breast cancer survivors

  This study is testing if fisetin, a natural compound from strawberries, can help improve physical function and overall well-being in postmenopausal women who have had chemotherapy for breast cancer.

  Recruiting at 7 sites Phase 2 Jonsson Comprehensive Cancer Center · Alhambra, California and 6 other locations · NCT05595499

• Combining letrozole and simvastatin to treat hormone receptor positive breast cancer

  This study tests if combining letrozole with simvastatin can help shrink tumors in postmenopausal women with hormone receptor positive breast cancer better than using letrozole alone.

  Recruiting at 4 sites Early Phase 1 Emory University · Atlanta, Georgia and 3 other locations · NCT05464810

• Using minoxidil to treat hair loss in breast cancer patients on endocrine therapy

  This study is testing if a hair loss treatment called minoxidil, given either as a foam or a pill, can help women with breast cancer who are losing their hair due to cancer therapy.

  Recruiting Early Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT05417308

• Time restricted eating for patients with HER2 negative breast cancer undergoing chemotherapy

  This study is testing if following a time-restricted eating schedule can help women with HER2 negative breast cancer feel better and respond better to chemotherapy.

  Recruiting at 5 sites Thomas Jefferson University · Cherry Hill, New Jersey and 4 other locations · NCT05327608

• Exercise intervention to improve cognitive function in breast cancer survivors

  This study tests whether a 6-month aerobic exercise program can help improve memory and attention in post-menopausal breast cancer survivors compared to those who only receive health education.

  Recruiting Mayo Clinic · Phoenix, Arizona · NCT04816006

• Combining WOKVAC vaccine with chemotherapy and targeted therapy for breast cancer treatment

  This study is testing if a new vaccine combined with chemotherapy and targeted therapy can help boost the immune response in breast cancer patients before surgery.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT04329065

• A tool to help patients decide on contralateral prophylactic mastectomy for breast cancer

  This study tests if an online tool can help women newly diagnosed with breast cancer make better choices about having a preventive mastectomy on the other breast.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT02918474

Related topics

Quick answers

How many Anatomic Stage II Breast Cancer AJCC v8 clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in United States (38 trials), Puerto Rico (5 trials), Mexico (1 trial), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 13, Phase 3: 6, Early Phase 1: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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