Blended e-Health Program to Help Women with Breast or Gynecologic Cancer Manage Fear of Cancer Progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares two 6-week programs designed to reduce fear of progression in women with stage I–IV breast or gynecologic cancer. One arm uses a Mindful Living Program with in-person group sessions, online content, and daily mindfulness practices; the other uses a Navigating Cancer Program with similar structure but different content. The study assesses feasibility and acceptability, along with changes in fear of progression and secondary outcomes like distress, anxiety, metacognition, and mindfulness. Participants are randomized to either arm and followed up 12 weeks after the start of the intervention. Eligible participants include adult English-speaking women with specified cancer stages who have functional fear of progression, regardless of current treatment status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women with stage III or IV GYN (ovarian, endometrial, cervical, vulvar/vaginal) or breast cancer who are at least 2 months from initial diagnosis OR Women with stage I or II endometrial, ovarian, or breast cancer with carcinosarcoma histology OR Women with stage I or II triple negative breast cancer
* Score ≥ 34 on the Fear of Progression Short-Form, indicating dysfunctional levels
* Age 18 or older; able to read and understand English
* Patients can be on active treatment or surveillance. They can be no evidence of disease (NED), recurrent or with progressive disease

Exclusion Criteria:

* Enrolled in hospice
* Ongoing uncontrolled active psychiatric condition that, in the opinion of the investigator, would interfere in the conduct of the study (e.g., mood disorders, psychosis disorders, or substance use), Major depression as assessed by Patient Health Questionnaire-9 (PHQ-9)
* Non-English speaking
* Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)
* Current participation in a mind-body or mindfulness education program within the past six weeks

Where it's running

• City of Hope at Arcadia
  Arcadia, California, United States Recruiting
• City of Hope Medical Center
  Duarte, California, United States Recruiting
• City of Hope at Seacliff
  Huntington Beach, California, United States Recruiting
• City of Hope at Irvine Lennar
  Irvine, California, United States Recruiting
• City of Hope Antelope Valley
  Lancaster, California, United States Recruiting
• City of Hope at Long Beach Elm
  Long Beach, California, United States Recruiting

Study contacts

• Principal investigator: Anne Reb — City of Hope Medical Center

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hypofractionated radiotherapy for non-metastatic breast cancer treatment

  This study is testing if giving a shorter course of radiation therapy before or after surgery can help women with non-metastatic breast cancer while causing fewer severe side effects.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06635980

• Personalized vaccine combined with pembrolizumab for advanced solid tumors

  This study is testing a new personalized cancer vaccine combined with pembrolizumab to see if it helps people with advanced solid tumors fight their cancer better.

  Recruiting Phase 1/2 Mayo Clinic · Jacksonville, Florida · NCT05269381

• Personalized Exercise Plan for Breast Cancer Survivors on Chemotherapy

  This trial tests whether adding a guided exercise program to a healthy-lifestyle education plan helps breast cancer patients undergoing chemotherapy maintain fitness, heart health, and quality of life.

  Recruiting at 3 sites Wake Forest University Health Sciences · Winston-Salem, North Carolina and 3 other locations · NCT07474090

• Sleep Changes and Biomarkers After Breast Cancer Treatment

  This project will see how sleep patterns and stress-related biological markers change from treatment through survivorship in people with stage I–III hormone receptor–positive breast cancer.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07341503

• Leuprolide versus goserelin to stop ovarian estrogen production in pre- or peri-menopausal women with breast cancer

  This study tests whether two doses of leuprolide or goserelin better stops the ovaries from making estrogen in pre- or peri-menopausal women with breast cancer.

  Recruiting Phase 2 University of Michigan Rogel Cancer Center · Ann Arbor, Michigan · NCT07158021

• Ultra‑short whole-breast radiation with lumpectomy cavity boost for stage I–III breast cancer

  This trial will test whether a very short course of whole‑breast radiation with a boost to the lumpectomy cavity works well and is safe for women age 40 and older with stage I–III breast cancer who had breast‑conserving surgery.

  Recruiting at 6 sites Phase 2 City of Hope Medical Center · Arcadia, California and 6 other locations · NCT06954831

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.