Personalized rTMS plus mixed-reality exercise for people with motor neuron disease
Official title: Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Run by Chulalongkorn University · NCT07067229 · Data updated 2026-11-12
This trial tests whether combining personalized rTMS with mixed-reality exercise games can slow disease progression and improve daily function in adults with mild-to-moderate motor neuron disease.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Chulalongkorn University Academic / other |
| Locations | 1 site (Bangkok, Pathumwan) |
| Status | Recruiting |
| Started | August 1, 2025 |
| Main results expected | August 30, 2027 |
| Study ends | December 30, 2027 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07067229 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 with a confirmed motor neuron disease diagnosis and mild-to-moderate severity (Sinaki‑Mulder levels 1–3) are the intended participants.
✕Probably not a fit
People with severe disease, those requiring ventilatory support, with other major neurological disorders (e.g., stroke), or with severe dementia are unlikely to benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial compares three groups: personalized repetitive transcranial magnetic stimulation (rTMS) with mixed-reality (MR) exergames, standard rTMS with MR exergames, and sham rTMS with MR exergames. Participants undergo detailed baseline testing including ALSFRS-R, PUMNS, PHQ-9, EQ-5D-5L, grip and hand function tests, FVC, TMS neurophysiology, EMG/MUNIX measures, and MRI, with follow-up at 3 and 6 months. Interventions are delivered according to the assigned arm and outcomes focus on functional scales, neurophysiology, and quality of life. The long-term goal is to translate an effective combined neuromodulation and exercise approach into clinical care for people with MND.
Why it matters
Potential benefit: If successful, this combined approach could slow symptom progression and improve quality of life and daily function for people with motor neuron disease.
How similar studies have gone: Small prior studies have shown rTMS can influence motor system measures, but combining personalized rTMS with mixed-reality exercise games is a novel approach with limited prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants aged between 18 and 80 years * Diagnosed with any type of motor neuron disease (MND) * Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3 Exclusion Criteria: * History of other neurological disorders, such as stroke * Use of ventilatory support * Severe dementia
Where it's running
-
King Chulalongkorn Memorial hospital, The Thai Red Cross Society
Bangkok, Pathumwan, Thailand Recruiting
Study contacts
- Principal investigator: Jakkrit Amornvit, MD — Chulalongkorn University
- Study coordinator: Jakkrit Amornvit, MD
- Email: jakkrit.a@chula.ac.th
- Phone: Thailand: 88-951-9195
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.