Personalized rTMS plus mixed-reality exercise for people with motor neuron disease
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
This trial tests whether combining personalized rTMS with mixed-reality exercise games can slow disease progression and improve daily function in adults with mild-to-moderate motor neuron disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Chulalongkorn University Academic / other |
| Locations | 1 site (Bangkok, Pathumwan) |
| Trial ID | NCT07067229 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial compares three groups: personalized repetitive transcranial magnetic stimulation (rTMS) with mixed-reality (MR) exergames, standard rTMS with MR exergames, and sham rTMS with MR exergames. Participants undergo detailed baseline testing including ALSFRS-R, PUMNS, PHQ-9, EQ-5D-5L, grip and hand function tests, FVC, TMS neurophysiology, EMG/MUNIX measures, and MRI, with follow-up at 3 and 6 months. Interventions are delivered according to the assigned arm and outcomes focus on functional scales, neurophysiology, and quality of life. The long-term goal is to translate an effective combined neuromodulation and exercise approach into clinical care for people with MND.
Who should consider this trial
Good fit: Adults aged 18–80 with a confirmed motor neuron disease diagnosis and mild-to-moderate severity (Sinaki‑Mulder levels 1–3) are the intended participants.
Not a fit: People with severe disease, those requiring ventilatory support, with other major neurological disorders (e.g., stroke), or with severe dementia are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, this combined approach could slow symptom progression and improve quality of life and daily function for people with motor neuron disease.
How similar studies have performed: Small prior studies have shown rTMS can influence motor system measures, but combining personalized rTMS with mixed-reality exercise games is a novel approach with limited prior evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants aged between 18 and 80 years * Diagnosed with any type of motor neuron disease (MND) * Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3 Exclusion Criteria: * History of other neurological disorders, such as stroke * Use of ventilatory support * Severe dementia
Where this trial is running
Bangkok, Pathumwan
- King Chulalongkorn Memorial hospital, The Thai Red Cross Society — Bangkok, Pathumwan, Thailand (Recruiting)
Study contacts
- Principal investigator: Jakkrit Amornvit, MD — Chulalongkorn University
- Study coordinator: Jakkrit Amornvit, MD
- Email: jakkrit.a@chula.ac.th
- Phone: Thailand: 88-951-9195
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.