Using augmented reality to improve communication for late stage ALS patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance the usability of a brain-computer interface (BCI) communication platform specifically designed for individuals with late stage ALS. Participants will receive the Cognixion Axon-R augmented reality device and associated software over a three-month period. The study will evaluate how quickly participants can learn to use the BCI, the effectiveness of alternative input methods like eye tracking, and the impact of AI-driven personalization on communication quality. Key metrics will include information transfer rate and system usability scale scores.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Must have someone (LAR) who can consent to their participation and who will be present in the study alongside the participant
* Must have a designated individual who can be trained on the Cognixion system
* Fluent in understanding English
* 18 years or older
* Must have ALS and need an assistive communication device
* Must be able to engage in volitional eye opening and sustain eye opening independently for x duration
* Must have a way to communicate apart from using the Cognixion device such as vocalizations, head nod, eye blinks, eyebrow raises, etc. At a minimum, reliable way of communicating "Yes" and "No"

Exclusion criteria:

* Disruption in English comprehension, either due to lack of fluent proficiency or due to a developmental/acquired language disorder (e.g. aphasia)
* Severely hearing impaired or deaf
* Sensitivity to flashing lights
* History of epilepsy and/or seizures
* Vision disorders restricting the visual field such as glaucoma, diplopia (double vision), nystagmus (involuntary eye movements)
* History of vertigo or other vestibular disorders
* Scalp that is prone to irritation, inflammation, injury, or infectious process

Where it's running

• Cognixion
  Santa Barbara, California, United States Recruiting

Study contacts

• Principal investigator: Chris Principal Investigator — Cognixion
• Study coordinator: Christopher Principal Investigator
• Email: chris@cognixion.com
• Phone: 8053200774

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Tongue-strengthening exercises for people with ALS

  This program will test whether daily tongue-strengthening exercises can help people with ALS maintain or improve speech and swallowing.

  Recruiting Nova Southeastern University · Davie, Florida · NCT07295990

• Registering medical data and care outcomes for ALS, SMA, and other motor disorders

  This registry slowly collects routine-care information from adults with ALS, SMA, or other motor disorders to see how they’re treated and how care affects outcomes.

  Recruiting Ambulanzpartner Soziotechnologie APST GmbH · Berlin, State of Berlin · NCT07900672

• Imaging markers for bulbar involvement in inclusion body myositis among IBM and comparison groups

  This study tests whether ultrasound and MRI can detect swallowing and bulbar muscle problems in people with inclusion body myositis.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07823101

• 7T MRI Pilot to Find Imaging Biomarkers in ALS and related motor neuron diseases

  A 7T MRI study is being done to see if ultra-high-field brain scans can reveal non-invasive biomarkers in adults with motor neuron disease, including ALS.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT07818772

• Biomarker Repository for Age-Related and Inherited Neurodegenerative Diseases

  This study collects blood and genetic samples from people with neurodegenerative diseases and their families to build a shared resource for studying disease risk and biology.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07798700

• Ultra-high-resolution PET imaging of aging, neurodegeneration, and psychotic disorders

  We will test whether ultra-high-resolution PET and 3T MRI scans can reveal early brain and spinal cord changes in healthy adults and people with Alzheimer's, Parkinson's disease, ALS, PSP, REM sleep behavior disorder, or psychotic disorders.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT07509125

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.