Comprehensive clinical rule to diagnose acute heart failure in the emergency department

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective observational study aims to develop a comprehensive prediction rule for diagnosing acute heart failure in the emergency department. It combines traditional clinical characteristics with point-of-care NT-proBNP testing, an 8-point lung ultrasound score, and rapid bedside echocardiography. The primary outcome is a validated diagnosis of acute heart failure, with secondary outcomes including ED and discharge diagnoses. The goal is to reduce diagnostic delays and improve accuracy to minimize potential harm to patients. The study is led by The Chinese University of Hong Kong with several collaborating hospitals in Hong Kong.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (aged ≥ 18 years)
* Suspected AHF or acute dyspnea
* Symptoms include shortness of breath, swelling of legs, orthopnea, paroxysmal nocturnal dyspnoea, exertional dyspnea or weight gain

Exclusion Criteria:

* Trauma patients
* Pregnancy
* Unstable patients requiring invasive airway intervention
* Patients who refuse to participate

Where it's running

• Prince of Wales Hospital
  Hong Kong, Hong Kong Recruiting
• Queen Mary Hospital
  Hong Kong, Hong Kong Not yet recruiting
• Tuen Mun Hospital
  Hong Kong, Hong Kong Not yet recruiting

Study contacts

• Principal investigator: Kevin KC Hung, Dr. — Chinese University of Hong Kong
• Study coordinator: Theresa Hui
• Email: theresahui@cuhk.edu.hk
• Phone: +85235051698

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Disrupted congestion in acute heart failure: can ultrasound at discharge predict readmission and death

  This study tests whether ultrasound checks of congestion at discharge can predict which patients with acute heart failure are more likely to be readmitted or die within 90 days.

  Recruiting University of Aarhus · Aarhus and 2 other locations · NCT07682298

• Pre-discharge Flu Vaccine for patients with acute heart problems

  This trial tests whether giving an influenza vaccine within 24 hours before hospital discharge helps patients who were treated for acute heart issues stay healthier this season.

  Recruiting Phase 4 Wroclaw Medical University · Wroclaw · NCT07617376

• Acute Heart Failure: How a Quantitative ECG Helps Clinicians

  This study tests whether quantitative ECG (QCG) measurements can reveal useful patterns in adults hospitalized with acute heart failure.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT07601022

• Urinary Sodium and Chloride Changes and Fluid Overload in Acute Heart Failure

  This study tests whether tracking urinary sodium and chloride during hospitalization can reflect congestion removal and predict short-term outcomes in adults with acute heart failure treated with IV diuretics.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Olot, Girona and 3 other locations · NCT07597512

• Training medical residents to use the Venous Excess Ultrasound (VExUS) score for bedside volume assessment

  This project tests whether in-person or remote training better teaches medical residents to use the VExUS ultrasound score for bedside volume checks in patients with acute heart failure.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT07541768

• Sarcopenia in older adults with acute heart failure: using muscle ultrasound and biomarkers to predict outcomes

  This study tests whether measuring muscle mass with ultrasound, along with muscle strength and biomarkers, can help predict outcomes for adults 80 and older hospitalized for acute heart failure with preserved ejection fraction.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid, Madrid · NCT07530029

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.