Evaluating residual congestion in patients with acute heart failure at discharge

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on assessing residual congestion in patients who have been hospitalized for acute heart failure. It employs a multiparametric approach to evaluate various indicators of congestion at the time of discharge, aiming to identify the most effective prognostic strategies. The study also incorporates artificial intelligence to develop a prognostic algorithm that enhances predictive accuracy compared to traditional methods. By comparing different evaluation techniques, the study seeks to improve risk stratification for patients with acute heart failure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Patients hospitalized for new onset heart failure or worsening heart failure defined by:

  1. Symptoms classified as New York Heart Association class III or IV.
  2. Clinical or instrumental signs of volume overload (e.g., dyspnea with evidence of pulmonary congestion on X-rays or lung ultrasound, pitting edema, and jugular venous distension).
  3. Elevated NT-proBNP levels within the first 24 hours of admission (cutoff values: 450 ng/L for patients \< 50 years; \>900 ng/L for patients aged 50-75 years; \>1800 ng/L for patients \>75 years).
* Ability to provide informed consent.

Exclusion Criteria:

* Known diagnosis of septicemia.
* Glomerular filtration rate \< 15 ml/min.
* Life expectancy \< 6 months.
* Active myocarditis.
* Heart transplant recipients.
* Patients with ventricular assist devices.
* Congenital heart diseases.
* Moderate-to-severe liver disease (Child-Pugh B-C).
* Patients that will not be followed up by the Heart Failure Unit.

Where it's running

• Complex Hospitalari Universitari Moisès Broggi
  Sant Joan Despí, Barcelona, Spain Recruiting

Study contacts

• Principal investigator: Giosafat Spitaleri, M.D. — Consorci Sanitari Integral
• Study coordinator: Giosafat Spitaleri, M.D.
• Email: gspitaleri@csi.cat
• Phone: +34 654471303

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.