Restrictive versus liberal fluid intake for patients hospitalized with acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares a thirst-driven liberal fluid-intake strategy with a fluid-restriction strategy in adults admitted for acute decompensated heart failure. Participants follow their assigned drinking plan during the hospital stay and for one month after discharge. The study will monitor time to clinical stability, safety outcomes, patient-reported thirst, and quality of life. Key endpoints include clinical stability and adverse events related to fluid management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \>18 years
2. Hospitalized for ADHF as the primary diagnosis, meeting both of the following:

   1. ≥1 documented symptom of new or worsening heart failure (dyspnea, fatigue, decreased exercise tolerance, or symptom of end-organ hypoperfusion).
   2. Objective evidence of ADHF, defined as either:

   i. ≥2 physical signs (edema, ascites, pulmonary rales/crackles, increased JVP, S3 gallop, rapid weight gain due to fluid retention), OR ii. ≥1 physical sign AND ≥1 laboratory finding indicative of ADHF (BNP \>500 ng/L or NT-proBNP \>2000 ng/L if sinus rhythm, or BNP \>750 ng/L or NT-proBNP \>3000 ng/L if atrial fibrillation, radiological/ultrasound evidence of pulmonary congestion, echocardiographic sign \[VCI \>2.1 cm, LVOT VTI \<15 cm, E/e' \>14, D-dominant pulmonary venous inflow pattern\], or invasive evidence \[CVP \>12 mmHg, PCWP \>18 mmHg, CI \<2.2 L/min/m2\]).
3. Treatment with ≥40 mg IV furosemide (or equivalent)
4. Enrolment within 24 hours of admission
5. Ability to provide informed consent

Exclusion Criteria:

1. Requirement at admission for ICU-level care, or IV inotropic/vasopressor therapy for ADHF.
2. Na+ \<125 mmol/L or Na+ \>145 mmol/L.
3. End-stage chronic kidney disease on chronic dialysis or eGFR \<15 mL/min/1.73 m2
4. Any condition which would make participation unsafe or substantially affect protocol adherence, as judged by investigator.

Where it's running

• Department of Cardiology, Gødstrup Hospital
  Herning, Denmark Recruiting

Study contacts

• Study coordinator: Anders Hostrup Larsen, MD, PhD
• Email: anders.hostrup@rm.dk
• Phone: 0045

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.