Disrupted congestion in acute heart failure: can ultrasound at discharge predict readmission and death

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter, observational cohort enrolling up to 580 adults with acute decompensated heart failure. Serial ultrasound assessments of congestion using VExUS and lung ultrasound (LUS) are performed within 48 hours of admission, at the switch from IV to oral diuretics, and on discharge, with discharge findings serving as the primary predictor. Treating clinicians are blinded to ultrasound results, and patients are followed by phone and chart review for 90 days, with extended follow-up at one year for selected outcomes. The goal is to determine if abnormal discharge ultrasound findings correlate with higher risks of heart failure readmission or all-cause mortality. No interventional treatment is tested in this observational design.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adults (≥18 years) admitted with ADHF.
2. Clinical evidence of congestion during admission, indicated by ≥1 of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiologic/ultrasound evidence of pulmonary congestion.
3. Treatment with ≥40 mg i.v. furosemide or equivalent dose loop diuretic during admission.

Exclusion Criteria:

1. Pregnancy
2. Moribund
3. Solitary kidney
4. Inability to provide written consent

Where it's running

• Aarhus University Hospital - Department of Cardiology
  Aarhus, Denmark Recruiting
• Copenhagen University Hospital, Amager and Hvidovre Hospital - Department of Cardiology
  Copenhagen, Denmark Not yet recruiting
• Zealand University Hospital - Department of Cardiology
  Roskilde, Denmark Not yet recruiting

Study contacts

• Study coordinator: Kristoffer Berg-Hansen, MD, PhD
• Email: krisbe@rm.dk
• Phone: +4560540700

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.