Urine-based algorithm to personalize diuretics for fluid relief in acute heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Ninety adults hospitalized for acute heart failure with clinical congestion will be randomized 1:1 to algorithm-guided versus usual care diuretic management. All participants receive IV furosemide with the initial dose set by the treating physician and a spot urine sample taken two hours after dosing to measure sodium and creatinine. A machine-learning tool uses those values to predict six-hour urine output and, in the algorithm arm, to guide the diuretic plan for the first 24 hours; the control arm receives physician-directed care without the tool. The approach focuses on early, personalized adjustment of loop diuretics to improve short-term decongestion outcomes during the hospitalization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients over 18 years of age who provide informed consent
* Ability to enroll in the study within the first 24 hours of hospitalization
* Primary reason for hospitalization is acute heart failure with signs of congestion (at least moderate lower extremity edema)
* NT-proBNP \> 1500 pg/ml
* Anticipated need for diuretic therapy for at least 48 hours from the time of study enrollment

Exclusion Criteria:

* End-stage kidney disease requiring renal replacement therapy
* Hemodynamic instability requiring inotropic support
* Active infection requiring intravenous antibiotic therapy

Where it's running

• Wroclaw Medical University
  Wroclaw, Dolnosląskie, Poland Recruiting
• Wroclaw Medical University
  Wroclaw, Lower Silesian Voivodeship, Poland Recruiting

Study contacts

• Study coordinator: Jan Biegus, MD, PhD
• Email: jan.biegus@umw.edu.pl
• Phone: 71 736 42 05

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.