Condition

Heart Failure - NYHA II - IV clinical trials and research

• 8Clinical trials
• 7Countries

Newest Heart Failure - NYHA II - IV clinical trials

All recruiting trials (8)

• Mitral Valve Edge-to-Edge Repair for exercise-induced severe mitral regurgitation in heart failure patients

  This trial tests whether adding mitral valve TEER to standard heart failure treatment helps people with exercise-triggered severe mitral regurgitation feel better and stay healthier.

  Recruiting at 2 sites Jena University Hospital · Düsseldorf and 1 other locations · NCT07709208

• AI-powered single-feature heart sound detector for heart failure patients

  A machine-learning tool using wearable ECG patches tests whether it can reliably identify heart sounds (S1, S2, and sometimes S3/S4) in adults with heart failure.

  Recruiting Vivalink · Hangzhou, Zhejiang · NCT07667452

• Understanding Exacerbations in Heart Failure: Monitoring with Apple Watch

  This study tests whether data from an Apple Watch, combined with clinical information, can help predict worsening heart failure in adults living with the condition.

  Recruiting University Health Network, Toronto · Newmarket, Ontario and 2 other locations · NCT07447908

• Using urine sodium to guide IV diuretic dosing for hospitalized acute heart failure

  This trial will test whether increasing IV diuretic doses to reach higher urine sodium levels helps hospitalized adults with acute decompensated heart failure remove more salt and fluid and have fewer readmissions.

  Recruiting Phase 4 Lakeland Regional Health Systems, Inc. · Lakeland, Florida · NCT07263035

• Can liver stiffness testing help detect high central venous pressure in heart failure patients

  A non-invasive FibroScan test is being used to see if liver stiffness can indicate elevated central venous pressure in adults with heart failure.

  Recruiting at 6 sites Echosens · Los Angeles, California and 6 other locations · NCT07222813

• Left bundle branch area pacing versus conventional cardiac resynchronization therapy for heart failure

  This study will test whether left bundle branch area pacing (LBBAP) works as well as or better than conventional cardiac resynchronization therapy (CRT) in adults with NYHA II–IV heart failure and reduced ejection fraction who are receiving a CRT‑D device.

  Recruiting at 40 sites Boston Scientific Corporation · Huntsville, Alabama and 42 other locations · NCT07069738

• Wearable chest patch that monitors heart mechanics for people with heart failure

  This project will try a small wearable chest patch that records heart movement (seismocardiography) and ECG to see if it can detect early worsening in adults with NYHA class II–IV heart failure.

  Recruiting at 2 sites Aalborg University · Aalborg, Denmark and 1 other locations · NCT06885164

• Peripheral factors that drive heart failure progression (PEDAL-HF)

  This trial will test whether heart-failure network care helps people recently hospitalized with acute decompensated heart failure (NYHA II–IV) improve biomarker levels and clinical outcomes compared with usual care.

  Recruiting University of Leipzig · Leipzig · NCT06656832

Related topics

Quick answers

How many Heart Failure - NYHA II - IV clinical trials are recruiting right now?

8, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in Germany (3 trials), United States (3 trials), France (1 trial), Poland (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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