Sponsor or institution
Clinical trials and research at University of Nebraska Medical Center
As of November 12, 2026, Find a Trial lists 430 NIH-funded research projects at this institution, with $209.6 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 430NIH research projects
NIH-funded research (newest 40 of 430)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
Digital malaria surveillance in Ethiopia to improve outbreak detection
A collaboration to add a malaria-specific digital module to an existing surveillance system in Africa to help detect and respond to outbreaks faster.
-
Cross-sector partnership uses digital malaria surveillance in Ethiopia
A US-based team will adapt and test a digital malaria surveillance module in SORMAS to help detect and respond to malaria outbreaks in Ethiopia.
-
Molecular and brain circuits linked to anxiety disorders
A researcher is studying a specific brain circuit to understand what drives anxiety and how it could be treated for people with anxiety disorders.
-
Modulating a brain lipid to reduce injury after newborn brain injury
Aims to test a treatment that changes a brain lipid to lessen damage after a baby’s brain has been deprived of oxygen.
-
Autonomic dysfunction in diabetes and erectile function: brain signals and kidney nerves
A study in diabetic rats explores how brain and kidney nerve signals may contribute to erectile dysfunction in diabetes, with findings that could inform future treatments for men with diabetes who have ED.
-
Multimodal bioelectroceutical approach to bone regeneration in diabetes and aging
A new approach uses electrical signals and tiny drugs inside special scaffolds to help jawbone heal in people with diabetes or aging-related bone problems.
-
Role of oxidative damage in gene regulation and aging
A researcher plans to study how a specific DNA damage from reactive oxygen species affects how genes are turned on or off, which could relate to aging and cancer.
-
Mpox-related eye disease: how the virus affects the eye and eye-keeper biomarkers
A medical research project will look at how mpox affects the eye, including biomarkers in tears and eye tissues, to better understand and monitor eye disease caused by mpox.
-
Mpox-related eye disease: tracking eye symptoms, antibodies, and biomarkers
Aimed at understanding how mpox affects the eye by studying eye-related symptoms, immune responses, and biomarkers to improve eye care for people affected by mpox.
-
Wiskott-Aldrich syndrome: how WASp protects the genome during cell stress
This NIH-funded project looks at how the WASp protein helps immune cells keep their DNA safe during cell stress, which could reduce cancer risk in WAS patients.
-
Chromatin remodeling and transcription shaping genome regulation
This project studies how the layout of DNA packaging and the machinery that reads genes influence which genes are turned on or off in human cells.
-
Fine-Scale genome folding and how it relates to gene transcription and location
This project studies how the genome’s 3D structure near genes relates to how genes are turned on and off inside human cells.
-
Cardiovascular data standards to speed AI in care and research
A nationwide effort to create a shared set of heart-related health data concepts to make AI and clinical systems work together more reliably.
-
Understanding how Coxiella manipulates fat in cells to grow
Aimed at finding new ways to treat chronic Q fever by studying how the Coxiella bacteria alter fat storage and use inside human cells.
-
Oral nicotine pouch use and its health effects across ages
This project looks at how oral nicotine pouches are used by teens and young adults and what health effects they may have.
-
How DNA ligase proteins help cells fix damaged DNA
This research looks at how DNA ligase proteins help cells fix damaged DNA, which could eventually help people whose cancers are linked to DNA repair problems.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
Targeted placental medicines to prevent pregnancy complications
A new approach uses tiny, placenta-homing nanoparticles to safely deliver drugs like aspirin and melatonin directly to the placenta to help prevent problems such as preeclampsia, poor fetal growth, and stillbirth.
-
Immune reprogramming with bioengineered scaffolds to treat brain infection after skull surgery
A research grant aims to test new bioengineered scaffolds that use the immune system to fight infections that can occur after craniotomy surgeries.
-
Oxidative stress and Nlrp3 inflammasome activation in eye lens aging
This grant looks at how aging and oxidative stress drive inflammation in the eye lens, which could help prevent age-related eye diseases.
-
Real-world use of quit aids in US adults
This project studies how well different quitting aids work in everyday life for adults in the United States who smoke.
-
Rapid autopsy biorepository to advance pancreatic and prostate cancer research
A special program collects high-quality tissues and body fluids within 5 hours of death to support pancreatic and prostate cancer research.
-
Molecular categorization of pediatric T-ALL using big data and AI
A pediatric leukemia grant that uses AI and big data from kids’ research to classify T-ALL subtypes and guide future treatments.
-
B7-H3 fluorescent probe to guide sarcoma surgery
A new B7-H3-targeted fluorescent probe is being developed to help surgeons see and remove all cancerous tissue during sarcoma operations.
-
Health Research Core accelerates clinical translational research across networks
A center at the University of Nebraska Medical Center funds small feasibility projects, development of independent investigators, and multi-site trials to advance regional clinical research.
-
Community Engagement and Outreach Core
A community-focused program that brings people with lived health experiences into the research process to help guide and improve clinical studies and communications.
-
RDCD Core: Design, Compliance, and Data Management for Clinical Research in the Great Plains
A centralized service hub helps researchers design better studies, manage data responsibly, and stay compliant to improve health in the Great Plains region.
-
Administrative Core powering regional biomedical research collaboration
A regional network led by nine partner institutions in Nebraska and nearby states uses strong governance and shared services to boost biomedical research capacity and translational work.
-
Great Plains CTR for child health and rural care powered by AI
A nationwide network focused on improving health care for children ages 0-11 in rural and urban Great Plains areas, using AI-enabled systems to speed up research and make care more accessible.
-
Fibronectin-coated nanoparticles for better tumor targeting
A new nanoparticle approach uses a fibronectin-rich coating to help drug-delivery particles reach and enter tumors more effectively.
-
Anti-adhesion barrier made from smart gels to prevent belly adhesions after surgery
A new gel-based barrier infused with an anti-inflammatory inhibitor is being developed to help people recover after abdominal surgery by preventing scar tissues that can stick organs together.
-
A map of how bacterial communities form and endure
A research project will map the single-cell gene activity in bacterial communities to understand how they form, organize, and survive in challenging environments.
-
Chromatin remodeling players across cell types in cancer
A scientist team is studying how complexes that rearrange DNA packaging control gene activity in cancer and during development.
-
How aging and HIV reservoirs interact with brain amyloid in older adults with HIV
This NIH grant explores how aging and HIV reservoirs may influence amyloid buildup linked to Alzheimer’s, with potential implications for older people living with HIV.
-
Role of brain cell ferritinophagy in HIV and cocaine-related brain inflammation
This project explores how a brain-cleanup process called ferritinophagy in microglia may be disrupted by HIV, cocaine, and their combination, potentially fueling inflammation and cognitive problems in people living with HIV.
-
How cell size affects how bowel lining cells fit together and stay healthy
A project to understand how differences in cell size in the gut lining influence tissue structure and disease, using mouse intestine as a model.
-
Understanding what drives lethal metastatic prostate cancer in men
This grant looks at why some prostate cancers become deadly and spread, using patient-derived cells and mouse models.
-
PIP Core: Smart small molecules to study proteins
A patient-friendly look at a program that develops tiny molecules to study proteins and how they work in the body, helping scientists understand disease targets.
-
Organoid Laboratory Core for Patient-Derived Models
A core facility is being funded to help researchers use patient-derived organoids to study breast and other tissues, including cancer, with support for growth, genetic tweaks, and animal and human tissue–based testing.
-
Single-Cell and Spatial Transcriptomics Core for disease research
This project provides low-cost access and expert help for single-cell and spatial RNA analyses to UNMC researchers studying diseases.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.