Role of oxidative damage in gene regulation and aging
Official title: Investigating roles for oxidative guanine damage in transcription regulation
Funded at University of Nebraska Medical Center · NIH-11591255 · Data updated 2026-11-12
A researcher plans to study how a specific DNA damage from reactive oxygen species affects how genes are turned on or off, which could relate to aging and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $249,000 |
| NIH project number | 4R00ES035871-03 |
| Project ID | NIH-11591255 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant is basic-science research and does not specify direct patient enrollment; however, insights may inform future studies involving individuals affected by age-related diseases or exposure to oxidative stress.
✕Less likely to help
No immediate patient participation is required for this project.
What this research studies
This project uses a special light-activated system to create a DNA damage called 8-oxoG at specific regions in the genome, allowing precise study of its impact on gene regulation. The work combines cutting-edge sequencing (ATAC-seq) to see how open or closed chromatin changes when damage occurs, and how these changes influence transcription. The aim is to understand how oxidative lesions modulate gene expression with spatial and temporal control, which could reveal new angles on age-related diseases and cancer. The research is conducted at the University of Nebraska Medical Center, with a focus on translating basic findings toward human health impact.
Why it matters
Potential benefit: If successful, the findings could inform strategies to prevent or mitigate gene-expression changes caused by oxidative stress relevant to aging and cancer.
How similar studies have gone: Preliminary work using targeted 8-oxoG generation has shown controllable induction and gene-expression changes, suggesting feasibility of the approach in human cells.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: De Rosa, Mariarosaria — University of Nebraska Medical Center
- Study coordinator: De Rosa, Mariarosaria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.