Multimodal bioelectroceutical approach to bone regeneration in diabetes and aging
Official title: Multimodal Bioelectroceutical Strategies for Alveolar Bone Regeneration in Diabetes and Aging
Funded at University of Nebraska Medical Center · NIH-11591547 · Data updated 2026-11-12
A new approach uses electrical signals and tiny drugs inside special scaffolds to help jawbone heal in people with diabetes or aging-related bone problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 26, 2026 |
| Project end | August 25, 2027 |
| Funding year | 2026 |
| Award (this year) | $383,750 |
| NIH project number | 1R56DE036161-01 |
| Project ID | NIH-11591547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with diabetes or age-related bone impairment who require dental implants or are at risk for poor bone healing.
✕Less likely to help
Patients without inflammatory bone issues or those not considering implants may see limited direct benefit.
What this research studies
This project aims to improve alveolar bone healing in patients with diabetes or aging-related bone decline by combining electrical stimulation, small-molecule drugs, and ionically conductive scaffolds. The method is designed to boost bone formation, blood vessel growth, and nerve repair while reducing chronic inflammation. Localized delivery within a biodegradable scaffold minimizes systemic side effects and supports sustained regenerative cues. The work builds on preliminary results in soft tissue repair to pursue bone regeneration in compromised hosts. If successful, it could lead to better implant success and long-term oral health for at-risk patients.
Why it matters
Potential benefit: If successful, patients could experience stronger, healthier jawbone that improves implant stability and longevity.
How similar studies have gone: Previous work showed proof-of-concept in soft tissue repair; this project extends the concept to bone regeneration.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Abdulmalik, Sama Abdulaziz — University of Nebraska Medical Center
- Study coordinator: Abdulmalik, Sama Abdulaziz
Related research
Other NIH-funded projects on the same topics.
-
Silver linings in midlife for women with HIV and diabetes
A short, friendly study looks at how women with HIV, diabetes, or both find positive meaning and stay engaged with care during perimenopause and menopause.
-
RNA m6A changes that age insulin-making beta cells in diabetes
This work explores whether changes in a common RNA chemical mark called m6A cause aging and loss of function in insulin-producing beta cells in adults with type 1 or type 2 diabetes.
-
Exploring how m6A mRNA methylation affects aging in pancreatic beta cells and diabetes
This study is looking at how a specific chemical change in the genetic material of insulin-producing cells in the pancreas affects their aging and function, especially in people with Type 1 and Type 2 diabetes, to find new ways to help these cells work better and survive longer.
-
Understanding how inflammation affects diabetes in older adults
This study is looking at how long-term inflammation and diabetes are related in older adults, especially how aging and nutrition might play a role, and it hopes to find ways to help seniors stay healthier by understanding these connections better.
-
HEARTS hypertension and diabetes care in Guatemala
This grant tests how well the HEARTS primary care model works in Guatemala to improve blood pressure and blood sugar control for patients.
-
Retinal signals in early diabetes and how they affect vision
This grant looks at how diabetes changes the signals in the retina that control vision, with a focus on inner retinal cells and how these changes may lead to vision problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.