How aging and HIV reservoirs interact with brain amyloid in older adults with HIV
Official title: Roles of Misfolded Protein Aggregates on Latent Reservoirs in SIV-infected, ART-treated Aged Rhesus Macaques
Funded at University of Nebraska Medical Center · NIH-11411766 · Data updated 2026-11-12
This NIH grant explores how aging and HIV reservoirs may influence amyloid buildup linked to Alzheimer’s, with potential implications for older people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | June 1, 2026 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $422,125 |
| NIH project number | 1R21AG102223-01 |
| Project ID | NIH-11411766 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are older adults living with HIV on ART and those interested in future dementia-related research; this grant uses animal models to understand underlying biology.
✕Less likely to help
Direct patient benefit is not guaranteed; findings may inform future approaches rather than immediate treatments.
What this research studies
As people living with HIV age, this study examines whether age-related amyloid plaques in the brain and blood may reactivate latent HIV reservoirs, potentially affecting disease progression. The project uses aged rhesus macaques treated with ART to mirror human aging and HIV treatment, focusing on how misfolded protein aggregates influence immune cells. By studying multiple amyloid-related proteins and immune responses, researchers aim to identify mechanisms that could guide future therapies. This work could shed light on why aging and HIV together raise dementia risk and how to prevent it in patients.
Why it matters
Potential benefit: Discoveries could inform strategies to prevent or delay dementia in older people living with HIV.
How similar studies have gone: Prior research links HIV, aging, and amyloid-related processes to cognitive decline, but this exact interaction in latent reservoirs is being explored.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Byrareddy, Siddappa N — University of Nebraska Medical Center
- Study coordinator: Byrareddy, Siddappa N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.