Chromatin remodeling and transcription shaping genome regulation
Official title: Interplay Between Transcription and ATP-dependent Chromatin Remodeling for Genome Regulation
Funded at University of Nebraska Medical Center · NIH-11519516 · Data updated 2026-11-12
This project studies how the layout of DNA packaging and the machinery that reads genes influence which genes are turned on or off in human cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | March 16, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $257,327 |
| NIH project number | 5P20GM121316-09 |
| Project ID | NIH-11519516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with developmental disorders, neurological conditions, or cancer related to chromatin regulation may benefit from future advances arising from this research.
✕Less likely to help
Direct patient benefit is not guaranteed during the grant period; progress may primarily advance basic scientific knowledge.
What this research studies
Researchers will explore how transcription factors and ATP-dependent chromatin remodelers work together to organize the genome in three dimensions and regulate gene activity. They will use advanced epigenomics techniques and biochemistry to map interactions across the genome and understand how these processes shape cell-type–specific gene expression. The findings could illuminate how disruptions in chromatin structure contribute to developmental disorders, neurological diseases, and cancer. The study aims to connect transcription, chromatin remodeling, and 3D genome organization in a comprehensive framework.
Why it matters
Potential benefit: Better understanding of how gene regulation works could lead to new strategies for diagnosing and treating diseases linked to chromatin misregulation.
How similar studies have gone: Prior work in chromatin remodeling and transcription has shown important links between genome organization and gene expression, with growing evidence of causal relationships.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Brahma, Sandipan — University of Nebraska Medical Center
- Study coordinator: Brahma, Sandipan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.