Chromatin remodeling players across cell types in cancer
Official title: Chromatin Remodeling Mechanisms Across Scales
Funded at University of Nebraska Medical Center · NIH-11429202 · Data updated 2026-11-12
A scientist team is studying how complexes that rearrange DNA packaging control gene activity in cancer and during development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | July 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $422,125 |
| NIH project number | 1R35GM166445-01 |
| Project ID | NIH-11429202 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with cancers linked to BAF mutations or dysregulated chromatin remodeling.
✕Less likely to help
Findings may not directly translate to immediate treatments for all cancer types.
What this research studies
This project looks at how BAF and related chromatin remodelers position DNA so genes turn on or off in different cell types, which affects cancer development and cellular differentiation. Researchers will map where these remodelers bind and how they interact with other regulators to produce cell-type specific gene expression. The work will use biochemical and genomic approaches to understand the rules that guide where and when BAF acts, aiming to connect mechanistic details to disease contexts like cancer.
Why it matters
Potential benefit: Better understanding of how chromatin remodeling influences cancer could guide new therapeutic strategies.
How similar studies have gone: Previous studies have shown that chromatin remodelers influence gene expression and cancer biology, supporting the plausibility of this approach.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Brahma, Sandipan — University of Nebraska Medical Center
- Study coordinator: Brahma, Sandipan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.