Mpox-related eye disease: tracking eye symptoms, antibodies, and biomarkers
Official title: Clinical and molecular biomarker surveillance in Mpox-related ocular disease
Funded at University of Nebraska Medical Center · NIH-11578611 · Data updated 2026-11-12
Aimed at understanding how mpox affects the eye by studying eye-related symptoms, immune responses, and biomarkers to improve eye care for people affected by mpox.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | August 1, 2026 |
| Project end | April 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $29,160 |
| NIH project number | 3R01EY038077-01A1S1 |
| Project ID | NIH-11578611 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with mpox who develop or are at risk for ocular involvement, including keratitis or other eye symptoms.
✕Less likely to help
Patients without mpox or without eye involvement may not directly benefit from this research.
What this research studies
If you have mpox and eye involvement, this project will analyze eye samples and clinical data to map how the virus affects the eye and vision. Researchers will look at antibody responses and biomarkers in tears and blood to understand disease pathways and potential targets for treatment. The study is anchored at the University of Nebraska Medical Center and involves collaboration with clinical and laboratory teams to translate findings into better eye care for mpox patients.
Why it matters
Potential benefit: It could lead to better diagnosis, monitoring, and treatments to prevent vision loss in mpox-related eye disease.
How similar studies have gone: Previous reports have noted ocular involvement in mpox and raised questions about ocular viral presence and immune responses; this study seeks to define these aspects more clearly.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Yeh, Steven — University of Nebraska Medical Center
- Study coordinator: Yeh, Steven
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.