Organoid Laboratory Core for Patient-Derived Models
Official title: Organoids Core
Funded at University of Nebraska Medical Center · NIH-11411441 · Data updated 2026-11-12
A core facility is being funded to help researchers use patient-derived organoids to study breast and other tissues, including cancer, with support for growth, genetic tweaks, and animal and human tissue–based testing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | March 16, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $110,018 |
| NIH project number | 5P20GM121316-09 |
| Project ID | NIH-11411441 on NIH RePORTER |
Who could benefit from this research
✓Could help
Researchers and clinicians who work with breast and other tissue models and who want to include PDOs in their studies.
✕Less likely to help
Direct patient participation is unlikely; the grant supports infrastructure and training rather than enrolling patients in a trial.
What this research studies
This grant funds a specialized organoid core to standardize and accelerate the use of patient-derived organoids (PDOs) for discovering drug targets and testing treatments. It provides expertise, training, reagents, and infrastructure so laboratories can grow and manipulate organoids that reflect the original patient tissue, including tumor and normal samples. The core also supports xenograft and in vitro studies to explore how organoids respond to therapies in a way that mirrors patient biology, aiming to lower barriers for adoption by multiple laboratories. The work emphasizes accessibility for the research community, enabling broader use of organoid systems in translational studies.
Why it matters
Potential benefit: If successful, patients could benefit from faster development of targeted therapies guided by organoid models that predict who will respond to treatment.
How similar studies have gone: Organoid models have shown faithful tissue characteristics and drug response patterns in many studies, with growing use in translational research.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Black, Adrian R — University of Nebraska Medical Center
- Study coordinator: Black, Adrian R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.