Fine-Scale genome folding and how it relates to gene transcription and location
Official title: Fine-Scale Genome Folding Relative to Transcription and Location
Funded at University of Nebraska Medical Center · NIH-11505733 · Data updated 2026-11-12
This project studies how the genome’s 3D structure near genes relates to how genes are turned on and off inside human cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 1, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $25,771 |
| NIH project number | 3R35GM147467-05S1 |
| Project ID | NIH-11505733 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients whose cells are studied to understand gene regulation and genome architecture, or who may benefit from future translational studies targeting chromatin organization.
✕Less likely to help
Healthy individuals or non-affected tissues used for methodological development may not directly benefit.
What this research studies
Researchers will map how small-scale genome folding changes as transcription proceeds, and they will develop tools to measure these fine-scale structures with greater sensitivity. They will also explore how the physical location inside the nucleus affects chromatin organization and gene activity. The work combines mechanistic experiments with software development to quantify sub-genic compartments and gene-loops in relation to transcription. Findings could clarify how the nucleus organizes genes during expressed states and reveal new patterns of genome control. The project aims to produce insights that may inform our understanding of gene regulation at a detailed, cell-by-cell level.
Why it matters
Potential benefit: A deeper understanding of how gene activity is controlled at the sub-genic level could inform future approaches to diagnose or treat diseases linked to gene regulation problems.
How similar studies have gone: Prior work shows that high-resolution chromatin features correlate with transcription, supporting the potential usefulness of this approach.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Rowley, Michael Jordan — University of Nebraska Medical Center
- Study coordinator: Rowley, Michael Jordan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.