Sponsor or institution

Clinical trials and research at University of Cape Town

• 7Clinical trials
• 35NIH research projects
• 6Countries

Newest trials

All recruiting trials (7)

• THUMB care package to reduce bleeding during and after caesarean section

  This project tests a perioperative care package called the 'Rule of THUMB' to reduce bleeding in people having a caesarean section.

  Recruiting University of Cape Town · Cape Town · NCT07005349

• Improving postoperative care to prevent deaths after surgery

  This study is testing a new approach to improve care after surgery to see if it can help prevent deaths from complications in patients in Ethiopia, South Africa, Tanzania, and Uganda.

  Recruiting University of Cape Town · Cape Town, Western Cape · NCT06997328

• Research on vaginal microbiomes in African women

  This study is trying to understand the different types of bacteria in the vagina of young women from South Africa and Kenya to see how they relate to HPV and inflammation.

  Recruiting at 2 sites University of Cape Town · Kisumu, Kisumu County and 1 other locations · NCT06662747

• B. Infantis to Boost Immunity in Infants Exposed to HIV

  This study is testing if giving a probiotic to infants born to HIV-positive mothers can help boost their immunity and improve their gut health during the first few months of life.

  Recruiting University of Cape Town · Cape Town · NCT05923333

• Gene expression profiles in spinal tuberculosis

  This study is trying to see if different gene patterns in spinal tuberculosis can help doctors better understand and treat the disease, especially in people with HIV.

  Recruiting University of Cape Town · Cape Town, Western Cape · NCT05610098

• Using Remote Ischaemic Conditioning to Improve Outcomes in STEMI Patients in Africa

  This study is testing if a treatment called Remote Ischaemic Conditioning can help reduce deaths and heart failure in people with a severe heart attack in Africa.

  Recruiting at 20 sites University of Cape Town · Mombasa, Mombasa County and 19 other locations · NCT04813159

• Using atorvastatin to reduce lung inflammation after tuberculosis treatment

  This study is testing if atorvastatin, a cholesterol-lowering drug, can help adults who have finished tuberculosis treatment by reducing lingering lung inflammation.

  Recruiting Phase 2/3 University of Cape Town · Observatory, WC · NCT04147286

NIH-funded research (35)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• African Genomics Data Hub: a centralized, well-organized home for African ancestry genetic data

  A project to create a centralized, high-quality resource of genomic data from people of African ancestry to help researchers and clinicians worldwide.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11419578

• ADHD in Kenya and South Africa: genetic and clinical profiling in children

  A study will enroll 6,000 children in Kenya and South Africa to collect detailed clinical data and DNA to better understand ADHD.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11372189

• Early brain development in kids of mothers with depression in different income settings

  This grant follows children up to age 6 to see how early brain growth varies for those born to mothers with depression, comparing high- and low-income settings in Africa.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11367490

• University of Cape Town HIV and TB Clinical Trials Unit

  This program runs clinical trials of new and improved HIV and tuberculosis treatments and prevention methods for people living in and around Cape Town, South Africa.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11234234

• How people in Africa understand big data in genetic medicine

  This project will learn what adults in Africa, including people with adult-onset diabetes, think and feel about using large genetic datasets for health care and research.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11177936

• How long BCG vaccine protection in the lungs and blood lasts against tuberculosis infection

  This project compares how long immune responses in the blood and lungs from BCG revaccination protect adolescents from becoming infected with tuberculosis.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11171372

• An open data science platform for health research in Africa

  This study is working on a new online platform that will help health researchers in Africa share and access important health data, making it easier for them to find new ways to improve health for patients like you.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11141937

• How substance use, mood, and brain development interact in young people living with HIV

  This project looks at how substance use, mood problems, and brain changes affect adolescents and young adults living with HIV in Cape Town.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11139635

• Understanding early brain growth in children whose mothers experienced depression

  This project looks at how brain development unfolds in young children whose mothers had depression, comparing those in different economic settings.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11136449

• Understanding ADHD in children in Kenya and South Africa

  This project is gathering information from children with and without ADHD in Kenya and South Africa to better understand the disorder's causes and how it affects them.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11113911

• Using health information to improve care for tuberculosis and HIV in Africa

  This project uses existing health records to better understand tuberculosis and HIV, especially in pregnant women, to improve care in South Africa.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11084565

• African Sickle Cell Data Hub

  This project runs a data hub to help researchers and clinics improve care for people with sickle cell disease in sub‑Saharan Africa.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11084302

• Investigating substance use and mental health in adolescents living with HIV in Cape Town

  This study is looking at the challenges that young people living with HIV in sub-Saharan Africa face, especially how using substances might affect their mental health and brain development, so we can better support them and help them cope during this important time in their lives.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11082673

• Developing New Tuberculosis Treatments by Focusing on Our Own Cells

  This project looks for new ways to treat tuberculosis by understanding how our own body's cells respond to the infection.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11073109

• Understanding the genetics of schizophrenia in the Xhosa people of South Africa

  This study is looking at how genes might play a role in schizophrenia, focusing on the Xhosa community in South Africa, and it involves 1250 people with schizophrenia and 1250 without it to help find specific genetic changes that could affect brain function.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11046516

• How maternal antibodies protect infants from group B Streptococcus and respiratory syncytial virus.

  This study is looking at how well antibodies from vaccinated mothers can help protect their babies, especially those at risk for HIV, from serious infections like group B Streptococcus and respiratory syncytial virus, which can be dangerous for newborns.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11010383

• Identifying urine metabolites that predict weight gain during pregnancy in South African women with HIV

  This study is looking at how certain substances in urine can help predict if women with HIV might gain too much weight during and after pregnancy, so we can find ways to support their health and prevent future issues like diabetes and heart problems.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-11000408

• A hub for health data science collaboration in Africa

  This study is all about bringing together data scientists and health experts in Africa to work as a team, share ideas, and use the best tools to come up with new ways to improve health for everyone.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10928254

• Creating a data platform to enhance biomedical research in Africa

  This study is creating a helpful online platform that gives researchers in Africa access to important tools and training for analyzing health data, so they can work together and make new discoveries that improve health in their communities.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10928252

• A platform for sharing and analyzing health data in Africa

  This study is working on a new platform to help researchers in Africa share and analyze health data more easily, while also providing training and support to boost local expertise, all with the goal of discovering new ways to improve health in communities across the continent.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10928251

• Understanding how big data can improve genomics medicine in Africa

  This study is looking at how big data can be used in healthcare in Africa, especially in genomics, by talking to patients, researchers, and data providers about their thoughts and feelings on using genetic information, while also considering important ethical issues.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10912568

• How depression in mothers affects brain development in children from different income backgrounds

  This study looks at how a mother's depression can affect her child's brain development from birth to age 11, especially in families with different income levels, and aims to find ways to help children grow up healthier.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10904874

• Building mental health research capacity in Africa

  The ARISE program is working to improve mental health care in Africa by training students and teachers to do important research and share knowledge, especially in light of challenges like the COVID-19 pandemic, so that everyone can benefit from better mental health support.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10890801

• Training in biomedical data science to address health challenges in Africa

  This study is creating a new graduate program at the University of Cape Town to help students learn how to use data science in healthcare, so they can solve important health challenges in Africa while understanding the ethical side of their work.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10886722

• Using automated image evaluation to improve cervical cancer screening for women with HIV

  This study is looking to make cervical cancer screening easier and more effective for women with HIV by using new technology to check images of the cervix along with HPV tests, helping to ensure they get the right care without unnecessary treatments.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10850713

• Improving kidney transplants between HIV-positive patients in South Africa

  This study is looking at how well kidney transplants work for people living with HIV, especially focusing on their health and the chances of their new kidney being accepted, to help improve transplant services for those in need in South Africa.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10840812

• Understanding how HIV-1 infections can be prevented using antibodies in sub-Saharan Africa

  This study is looking at how well an antibody called VRC01 can help prevent HIV-1 infections in people in sub-Saharan Africa, and it aims to understand how different virus strains react to it, which could lead to better ways to protect against HIV in the future.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10840452

• Investigating how different injectable contraceptives affect HIV-1 infection risk in women.

  This study is looking at how two types of birth control shots might affect the risk of getting HIV-1 in young women in sub-Saharan Africa, so we can better understand their safety and help keep women healthy.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10815728

• Understanding HIV-1 reservoirs in African women

  This study is looking at how HIV-1 hides in the bodies of South African women, comparing it to other groups, to help us understand why it stays there and to find better ways to treat and possibly eliminate the virus in the future.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10809617

• Finding new uses for existing drugs to treat malaria

  This study is looking for new ways to treat malaria by using some medicines already approved for other diseases, like cancer, to help create effective pills that can tackle different stages of the malaria parasite and improve treatment options for people affected by this illness.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10808058

• Improving cognitive skills in people with HIV in South Africa.

  This study is working on new brain training programs to help people living with HIV in South Africa improve their thinking skills and daily life, so they can feel better and function well.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10798288

• Training program for managing mental health in people living with HIV

  This study is working on a training program to help healthcare providers in South Africa better support people living with HIV, especially those dealing with mental health issues like depression and PTSD, so they can improve their overall health and stick to their treatment plans.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10798282

• Effects of HIV medications during pregnancy on infant gut health and development

  This study is looking at how different medications taken by pregnant women with HIV might affect the gut health and development of their babies who are not infected, to help understand how these treatments can influence their little ones' health.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10789993

• Investigating how long the BCG vaccine protects against tuberculosis infection

  This study is looking at how well the BCG vaccine protects against tuberculosis over time, especially in teenagers who are more likely to get the disease, by checking their blood and lung samples to find out how their immune system responds.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10676971

• Understanding pain and distress in people living with HIV and developing coping strategies.

  This study is looking at how stress and inflammation affect chronic pain in people with HIV, and it aims to create helpful coping strategies that can be used in places with fewer resources, so that patients can feel better and improve their quality of life.

  NIH research University of Cape Town · Rondebosch, South Africa · NIH-10610321

Quick answers

How many clinical trials run by University of Cape Town are recruiting right now?

7, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in South Africa (7 trials), Kenya (2 trials), Mozambique (1 trial), Senegal (1 trial), Sudan (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2/3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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