Clinical trial Recruiting at 1 site Observational Ages 18 to 100

Improving postoperative care to prevent deaths after surgery

Official title: '5 Rs to Rescue' A Cluster Trial With an Embedded Process Evaluation

Run by University of Cape Town · NCT06997328 · Data updated 2026-11-12

This study is testing a new approach to improve care after surgery to see if it can help prevent deaths from complications in patients in Ethiopia, South Africa, Tanzania, and Uganda.

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment6000 (estimated)
SponsorUniversity of Cape Town
Academic / other
Locations1 site (Cape Town, Western Cape)
StatusRecruiting
StartedSeptember 1, 2024
Main results expectedFebruary 1, 2026
Study endsSeptember 1, 2026
Registry record updatedJanuary 23, 2026
Trial IDNCT06997328 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are patients aged 18 years and older undergoing any type of surgery who will receive postoperative care in participating wards.

Probably not a fit

Patients who are receiving end-of-life care or choose to opt out of the trial will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to address the issue of 'failure to rescue', which refers to preventable deaths following surgery due to complications that are not timely identified and treated. The study will implement a quality improvement intervention known as the '5 Rs to Rescue' across 20 centers in Ethiopia, South Africa, Tanzania, and Uganda. This intervention focuses on enhancing patient management through risk assessment and improved monitoring of vital signs post-surgery. By evaluating the effectiveness of this intervention, the study seeks to increase the surveillance of at-risk patients and ultimately reduce postoperative mortality in resource-limited settings.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce postoperative mortality rates in African hospitals.

How similar studies have gone: Previous studies have highlighted the importance of early warning systems in preventing postoperative complications, suggesting that this approach could be effective, although the specific '5 Rs to Rescue' intervention is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged 18 years and older undergoing any surgery, who receive postoperative care on a participating ward

Exclusion Criteria:

* Patients who opt out of trial participation.
* Patients receiving end of life care.

Where it's running

  • Groote Schuur Hospital
    Cape Town, Western Cape, South Africa
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.