Sponsor or institution

Clinical trials and research at State University of New York at Albany

• 85NIH research projects

NIH-funded research (newest 40 of 85)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Cross-disease small molecule therapy for CAG expansion spinocerebellar ataxias

  A new NIH grant is exploring whether existing and natural small molecules can lower harmful CAG RNA and proteins across several spinocerebellar ataxias to help people with these conditions.

  NIH research State University of New York at Albany · Albany, United States · NIH-11617807

• New small molecule therapeutics to help myotonic dystrophy

  A new NIH-funded project tests specially designed small molecules to lower harmful RNA activity in myotonic dystrophy and related diseases, aiming to reduce disease-driving RNA effects.

  NIH research State University of New York at Albany · Albany, United States · NIH-11617693

• Biofilm structure and its role in the start of gum disease

  A researchers team will study how tiny communities of bacteria at the gumline interact with the mouth’s tissues to spark inflammation that leads from healthy gums to periodontal disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11597609

• Understanding how unusual RNA translation happens in neurological diseases

  Researchers are studying how RNAs can start making proteins in unexpected ways in neurodegenerative diseases, which could reveal new targets for therapy.

  NIH research State University of New York at Albany · Albany, United States · NIH-11581694

• Early-life neighborhood redlining and lifetime mortality in a historical cohort

  This project looks at whether growing up in areas graded or disinvested by HOLC in the 1930s affects mortality later in life for people born in 1930–1940.

  NIH research State University of New York at Albany · Albany, United States · NIH-11454826

• Activating PTP1B and Other Phosphatases with Small Molecules

  A safety-focused, patient-friendly look at a project that aims to turn on natural enzymes in our cells to help correct harmful signals in diseases.

  NIH research State University of New York at Albany · Albany, United States · NIH-11442911

• Count-aware modeling for counting-based spectral unmixing in tissue imaging

  A small NIH grant aims to improve how we separate multiple molecular signals in tissue images by using models that respect the way photons are counted, helping researchers get clearer results from fluorescent images.

  NIH research State University of New York at Albany · Albany, United States · NIH-11442149

• PrEP-WISE: A peer-led program to boost PrEP use among marginalized Black cisgender women

  A peer-led program called PrEP-WISE aims to help Black cisgender women in New York start and stay on PrEP to prevent HIV.

  NIH research State University of New York at Albany · Albany, United States · NIH-11423359

• RNA-based biosensing and DNA nanotechnology to detect and analyze nucleic acids

  A research project to create new RNA- and DNA-based tools that detect and measure nucleic acids, with potential uses in disease diagnostics and biotechnology.

  NIH research State University of New York at Albany · Albany, United States · NIH-11404395

• Astrocyte glutamate transporter (EAAT2/GLT1) failure in Alzheimer's

  Researchers want to learn whether problems with a brain support protein that clears glutamate contribute to memory loss in people with Alzheimer's disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11403594

• Biofilm structure and how it starts periodontal disease in humans and dogs

  A scientist team will study how sticky mouth biofilms and special bacteria may start gum disease in adults, using human teeth and dog models.

  NIH research State University of New York at Albany · Albany, United States · NIH-11402600

• How dental plaque structure may trigger gum disease

  Researchers are comparing the arrangement and activity of bacteria in plaque from adults with healthy gums, gingivitis, and periodontitis to learn how plaque changes can start gum disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11397657

• PTP1B and thyroid hormone signaling in heart hypertrophy

  A study in patients and models to understand how a heart protein (PTP1B) affects heart enlargement and function when stress happens, with potential ways to protect the heart.

  NIH research State University of New York at Albany · Albany, United States · NIH-11384142

• Non-Canonical Translation in Neurological Disease: How RNA Shapes Misbehavior in Junkie Repeats

  This research looks at how certain RNA structures around CAG repeats can cause unusual protein production in neurological diseases, aiming to understand why these diseases happen and how to intervene for patients.

  NIH research State University of New York at Albany · Albany, United States · NIH-11379534

• Understanding how stress in Black mothers affects moms and babies across generations

  A study to learn how stress from family and surroundings affects health for Black mothers and their babies, now and in future generations.

  NIH research State University of New York at Albany · Albany, United States · NIH-11374866

• Programmable DNA Nanostructures as Biomedicine Scaffolds

  A grant to develop DNA-based nanostructures that can carry drugs and help scientists study disease structures, with plans to test in cell cultures and animal models.

  NIH research State University of New York at Albany · Albany, United States · NIH-11373563

• Translational regulation in exposure biology and how cells reprogram tRNA to handle toxins

  This grant studies how human and rat cells change RNA modifications to cope with harmful exposures, aiming to reveal new ways cells prioritize stress-response proteins.

  NIH research State University of New York at Albany · Albany, United States · NIH-11367908

• Population and evolution of recombining genes in bacteria

  This grant studies how bacteria swap genetic material to gain new traits, which can affect disease and antibiotic resistance, with results that could inform better treatments and tracking of bacterial threats.

  NIH research State University of New York at Albany · Albany, United States · NIH-11329857

• How oxidation controls key protein switches in cells

  Researchers are looking at how small oxidation changes switch off protein regulators in cells, which could help people with diseases linked to oxidative stress.

  NIH research State University of New York at Albany · Albany, United States · NIH-11324569

• How the gene regulator Gli3 influences Kallmann syndrome and normosmic hypogonadotropic hypogonadism

  Researchers are looking at whether changes in the gene regulator Gli3 help explain why some adults develop Kallmann syndrome or normosmic idiopathic hypogonadotropic hypogonadism.

  NIH research State University of New York at Albany · Albany, United States · NIH-11321670

• Understanding how salivary glands can regenerate after radiation damage

  This study is looking at how salivary glands can heal after being damaged by radiation treatment for head and neck cancer, with the hope of finding better ways to help people who experience dry mouth and other issues afterward.

  NIH research State University of New York at Albany · Albany, United States · NIH-11311177

• Small-molecule medicines targeting myotonic dystrophy

  New small-molecule medicines aim to lower the toxic RNAs that cause symptoms in people with myotonic dystrophy.

  NIH research State University of New York at Albany · Albany, United States · NIH-11307593

• Reducing scarring to help salivary glands regenerate

  This research aims to reduce scar tissue in salivary glands to help people with dry mouth after radiation or Sjögren’s syndrome regain gland function.

  NIH research State University of New York at Albany · Albany, United States · NIH-11307580

• DNA nanosensors and precision therapies for infections

  This project aims to build DNA-based sensors and tiny, controllable therapeutics to help detect and treat bacterial and viral infections for patients.

  NIH research State University of New York at Albany · Albany, United States · NIH-11252304

• Developing drugs to block toxic CAG expansions in spinocerebellar ataxias

  Looking for approved drugs and natural compounds that can lower harmful CAG‑expanded RNA and proteins to help people with CAG‑expansion spinocerebellar ataxias.

  NIH research State University of New York at Albany · Albany, United States · NIH-11238900

• How early nerve development affects smell, puberty, and fertility

  Researchers are looking at how early nerve pathways guide the brain cells that control puberty and fertility in people with conditions like Kallmann syndrome and related infertility.

  NIH research State University of New York at Albany · Albany, United States · NIH-11235887

• How Ilheus virus infects mosquito and mammal cells

  Researchers will learn how Ilheus virus grows in mosquito and mammal cells to help protect people from mosquito-borne illness.

  NIH research State University of New York at Albany · Albany, United States · NIH-11232316

• How unusual RNA-driven protein production may cause nerve and brain disorders

  Researchers are looking at how certain RNAs can make unexpected proteins that may contribute to diseases caused by CAG repeat expansions, like Huntington’s and some ataxias.

  NIH research State University of New York at Albany · Albany, United States · NIH-11179351

• Investigating small molecule treatments for spinocerebellar ataxias caused by CAG expansion mutations.

  This study is looking for new treatment options for people with spinocerebellar ataxias, a group of rare disorders that affect balance and coordination, by testing existing medications and natural products to see if they can help reduce the problems caused by specific genetic mutations.

  NIH research State University of New York at Albany · Albany, United States · NIH-11177309

• How specific proteins shape face and skull development

  This project explores how certain proteins guide the development of the face and skull, aiming to understand conditions like cleft palate and a smaller lower jaw.

  NIH research State University of New York at Albany · Albany, United States · NIH-11161165

• Tiny DNA Structures for Delivering Medicines and Imaging

  This project explores using specially designed DNA structures to deliver medicines more effectively and for better imaging, particularly for conditions like myotonic dystrophy type 1.

  NIH research State University of New York at Albany · Albany, United States · NIH-11143868

• Exploring how a specific protein affects puberty and fertility in certain genetic conditions

  This study is looking at how a specific protein called Gli3 affects Kallmann syndrome and a related condition that can cause delayed puberty and infertility, with the goal of understanding how important brain cells develop and move during pregnancy, which could help find better treatments for these issues.

  NIH research State University of New York at Albany · Albany, United States · NIH-11143167

• How dental plaque structure changes when gums go from healthy to disease

  This project looks at how groups of bacteria in plaque at the gum line change in adults with healthy gums, gingivitis, or chronic periodontitis.

  NIH research State University of New York at Albany · Albany, United States · NIH-11143120

• Tools to detect RNA and build tiny DNA devices for sensing and drug delivery

  Creating easy, low-cost RNA tests and tiny DNA-based devices that could help people needing better diagnostics or targeted treatments.

  NIH research State University of New York at Albany · Albany, United States · NIH-11135587

• Investigating new treatments for spinocerebellar ataxias caused by genetic mutations.

  This study is looking for new treatments for spinocerebellar ataxias, which are rare disorders that affect coordination, by testing existing medications and natural products to see if they can help reduce the problems caused by certain genetic mutations.

  NIH research State University of New York at Albany · Albany, United States · NIH-11128426

• Understanding How Microbes Form Dental Plaque

  This project looks at how tiny organisms in your mouth come together to form dental plaque, which can lead to gum disease.

  NIH research State University of New York at Albany · Albany, United States · NIH-11128345

• How insurance rules about intoxication affect drinking and injury care

  This project looks at whether state insurance laws that let insurers deny coverage for alcohol-related injuries change people's drinking, blood-alcohol testing after injury, and related outcomes.

  NIH research State University of New York at Albany · Albany, United States · NIH-11127765

• How extreme weather and power outages affect the health of older adults with Alzheimer's

  Looking at how heatwaves, floods, storms, and blackouts impact the health and safety of older adults living with Alzheimer's, especially those with fewer resources.

  NIH research State University of New York at Albany · Albany, United States · NIH-11126584

• How Our Cells Respond to Harmful Substances

  This research explores how our cells change their internal instructions when exposed to harmful chemicals, focusing on tiny changes in RNA that help cells cope.

  NIH research State University of New York at Albany · Albany, United States · NIH-11121003

• Understanding how stress affects Black mothers and their babies across generations

  This project looks at how stress experienced by Black mothers, both in their lives and passed down through generations, impacts the health of both mothers and their infants.

  NIH research State University of New York at Albany · Albany, United States · NIH-11120837

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