How specific proteins shape face and skull development
Functional Characterization of Mediator Complex Proteins in Neural Crest and Craniofacial Development
This project explores how certain proteins guide the development of the face and skull, aiming to understand conditions like cleft palate and a smaller lower jaw.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-11161165 on NIH RePORTER |
What this research studies
Craniofacial developmental disorders, such as cleft palate and a smaller lower jaw (retrognathia), are common and often result from issues with special cells called neural crest cells. While we know some genetic causes for these conditions, many cases still lack a clear genetic explanation. This project focuses on a gene called Med23, which has been identified as crucial for proper face and skull development. Researchers are using models to understand how Med23 functions within neural crest cells and other cell types, and how its malfunction leads to these developmental problems. The ultimate goal is to uncover the specific roles of Med23 and related proteins to better understand the complex origins of these conditions.
Who could benefit from this research
Good fit: Patients with craniofacial developmental disorders, such as cleft palate, retrognathia, or conditions like 22q11 deletion syndrome, could benefit from the knowledge gained from this work.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this foundational laboratory-based research.
Why it matters
Potential benefit: If successful, this research could lead to a deeper understanding of the genetic and cellular causes of craniofacial disorders, potentially guiding future diagnostic tools or interventions.
How similar studies have performed: While genetic links to some craniofacial conditions are known, this specific focus on the Med23 gene and its role in neural crest cell development represents a novel area of investigation.
Where this research is happening
Albany, United States
- State University of New York at Albany — Albany, United States (Active)
Researchers
- Principal investigator: Dash, Soma — State University of New York at Albany
- Study coordinator: Dash, Soma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.