Translational regulation in exposure biology and how cells reprogram tRNA to handle toxins
Official title: Translational regulation in exposure biology - Xenobiotic-induced reprograming of tRNA modifications and selective translation of codon-biased response genes in rat and human models
Funded at State University of New York at Albany · NIH-11367908 · Data updated 2026-11-12
This grant studies how human and rat cells change RNA modifications to cope with harmful exposures, aiming to reveal new ways cells prioritize stress-response proteins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 1, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $440,279 |
| NIH project number | 5R01ES026856-11 |
| Project ID | NIH-11367908 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with exposure to arsenic or related toxicants, or those with diseases linked to toxin exposure, could benefit from advances in biomarkers and therapies arising from this work.
✕Less likely to help
Direct participation by patients is not described; the research uses cell lines and animal tissues, so immediate patient involvement is unlikely.
What this research studies
Researchers will use advanced RNA modification detection and sequencing technologies to map changes in tRNA and translation when cells encounter toxic substances. The work connects animal models and human cell lines to understand how specific RNA changes influence which proteins are made during stress. This could identify biomarkers and targets for protecting cells from damage caused by arsenic and related compounds. The project builds on previous findings that link toxin exposure to codon-biased translation and key stress pathways.
Why it matters
Potential benefit: New insights could lead to better biomarkers and strategies to mitigate toxin-induced cellular damage in humans.
How similar studies have gone: Prior work shows tRNA modifications respond to toxic exposures, suggesting translational changes are a viable mechanism to explore further.
Where this research is happening
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State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Begley, Thomas J — State University of New York at Albany
- Study coordinator: Begley, Thomas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.