How oxidation controls key protein switches in cells
Complexity of Protein Tyrosine Phosphatase Oxidation
Researchers are looking at how small oxidation changes switch off protein regulators in cells, which could help people with diseases linked to oxidative stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-11324569 on NIH RePORTER |
What this research studies
This lab project will map how protein tyrosine phosphatases (important regulators of cell signaling) are reversibly turned off by oxidation using biochemical tools and cellular models. The team will identify new oxidation and reduction mechanisms they recently discovered and test how these changes alter cell signaling and function. Work will include experiments in cultured cells and in vivo models to track oxidation states, manipulate specific proteins, and observe downstream effects. The aim is to find molecular targets that could guide future therapies for conditions driven by disrupted redox signaling.
Who could benefit from this research
Good fit: Although this is primarily lab-based and not enrolling patients now, people with conditions tied to oxidative stress or dysregulated cell signaling (for example certain cancers, neurodegenerative, or heart diseases) would be the kinds of patients who might benefit from future treatments arising from this work.
Not a fit: Patients with conditions that do not involve oxidative signaling pathways or where disease mechanisms are purely structural or non-redox related are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to new ways to restore proper cell signaling and lead to therapies for diseases linked to oxidative stress, such as some cancers, neurodegenerative, and cardiovascular conditions.
How similar studies have performed: Previous research has shown that oxidation of protein tyrosine phosphatases affects cell signaling and disease, but the specific oxidation-relay mechanisms proposed here are recently described and remain to be validated.
Where this research is happening
Albany, United States
- State University of New York at Albany — Albany, United States (Active)
Researchers
- Principal investigator: Boivin, Benoit — State University of New York at Albany
- Study coordinator: Boivin, Benoit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.