Programmable DNA Nanostructures as Biomedicine Scaffolds
Official title: Programmable DNA Nanostructures as Biomedical and Structural Scaffolds
Funded at State University of New York at Albany · NIH-11373563 · Data updated 2026-11-12
A grant to develop DNA-based nanostructures that can carry drugs and help scientists study disease structures, with plans to test in cell cultures and animal models.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $391,250 |
| NIH project number | 5R35GM150672-04 |
| Project ID | NIH-11373563 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients with multisystemic diseases or conditions where targeted drug delivery and advanced imaging could improve outcomes, and in whom DM1-related pathways are relevant for preclinical testing.
✕Less likely to help
Early-stage or non-targeted studies may not offer direct benefits to patients.
What this research studies
This project aims to build DNA-based nanostructures that can precisely position molecules like antibodies and drugs. It covers creating a robust drug-delivery platform for multisystem diseases and developing 3D DNA crystals to aid structural biology studies using advanced X-ray techniques. The work will test drug loading, delivery efficiency, and safety from cells to preclinical mouse models, focusing on bioavailability and targeting. The research plans to demonstrate how these DNA carriers behave in biological systems and how they can improve drug screening and disease understanding.
Why it matters
Potential benefit: If successful, patients could benefit from more precise drug delivery and better tools for diagnosing and studying diseases.
How similar studies have gone: Previous work in DNA nanotechnology has shown potential for targeted delivery and imaging, with ongoing translation efforts.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Chandrasekaran, Arun Richard — State University of New York at Albany
- Study coordinator: Chandrasekaran, Arun Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.