PTP1B and thyroid hormone signaling in heart hypertrophy
Official title: Role of Protein Tyrosine Phosphatase 1B in Cardiac Hypertrophy
Funded at State University of New York at Albany · NIH-11384142 · Data updated 2026-11-12
A study in patients and models to understand how a heart protein (PTP1B) affects heart enlargement and function when stress happens, with potential ways to protect the heart.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | June 15, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $530,541 |
| NIH project number | 5R01HL175391-03 |
| Project ID | NIH-11384142 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients with or at risk for heart hypertrophy and heart failure, or those who could contribute tissue or data for translational studies under appropriate consent.
✕Less likely to help
Patients without cardiac hypertrophy or related conditions may not directly benefit from this work.
What this research studies
This project explores how oxidative stress in the heart alters a key protein, PTP1B, and how that change influences thyroid hormone signaling during cardiac hypertrophy. Researchers will test molecular mechanisms in heart cells and animal models, and they will examine strategies to keep PTP1B active to prevent harmful heart remodeling. The work aims to identify new approaches that could preserve heart function and prevent heart failure in conditions of high blood pressure or stress. By exploring a peptide-based strategy to prevent PTP1B inactivation, the study may point toward novel therapies.
Why it matters
Potential benefit: If successful, the research could lead to new treatments that protect heart function and prevent heart failure in patients with cardiac hypertrophy.
How similar studies have gone: Previous work has shown that modulating PTP1B and thyroid hormone signaling can influence cardiac remodeling in model systems, with promising but preliminary results.
Where this research is happening
-
State University of New York at Albany
Albany, United States Active
Researchers
- Principal investigator: Boivin, Benoit — State University of New York at Albany
- Study coordinator: Boivin, Benoit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.