Sponsor or institution
Clinical trials and research at Sanford Research/usd
As of November 12, 2026, Find a Trial lists 33 NIH-funded research projects at this institution, with $14.7 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 33NIH research projects
NIH-funded research (33)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Community-based cancer research to improve care and trials in rural areas
A rural cancer research program is expanding access to modern cancer trials, prevention, and care delivery improvements for people living across the upper Midwest.
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Genetic clues to how molybdenum cofactor supports life
Aiming to understand how molybdenum cofactor keeps essential body chemistry running, using a worm model to uncover pathways that could inform human metabolic diseases.
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Understanding how early neural stem cells grow to form the cortex and how this affects autism
Researchers are studying how early brain cells divide and become different types, which can influence autism and other neurodevelopmental conditions.
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GPCR signaling: how these receptors talk to many proteins in the body
This project looks at how GPCRs communicate with different G proteins to influence many body processes and drug responses.
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Sanford Community Cancer Program — cancer trials and care for the North Central Plains
This program brings NCI-supported cancer clinical trials, prevention efforts, and care-improvement projects to patients across the rural North Central Plains.
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How brain cells build and remodel tiny antennas called cilia to control signals
Scientists are studying how tiny brain cell antennas, called primary cilia, form and remodel to help brain cells communicate and develop properly.
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How kidney tubule cells move important proteins and salts
This project aims to find how motor proteins called MYH9 and MYH10 in adult kidney tubule cells control movement of proteins and salt transport linked to some forms of kidney disease.
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How platinum chemotherapy reshapes the tumor's surrounding support in ovarian cancer
Researchers will track how platinum chemotherapy changes the tumor’s surrounding support structures in high-grade serous ovarian cancer to learn why tumors often return.
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How p53 and Notch genes drive childhood bone cancer (osteosarcoma)
This project looks at how changes in the p53 and Notch genes in bone-forming cells contribute to osteosarcoma in children.
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Nerves inside head and neck tumors and pain
This research looks at how nerve cells inside head and neck tumors cause pain, with the goal of helping people who have head and neck cancer.
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Molecular Regulators of Collecting Duct Remodeling
A study with adults looking at how kidney collecting duct cells change and affect water balance, especially in people with Alagille syndrome or bipolar disorder.
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Changing a mother's diet to protect children's and grandchildren's heart health
This project looks at whether lowering a pregnant woman's dietary fat and related interventions can protect children and future grandchildren from heart damage linked to gestational diabetes.
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New mouse models that mirror high-risk childhood rhabdomyosarcoma
Researchers are creating mouse versions of high-risk childhood rhabdomyosarcoma to test whether blocking the NOTCH1 pathway can slow tumor growth.
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Understanding cancer causes and prevention strategies
This study is looking for people to help us understand what causes cancer and how we can prevent it by sharing their health habits and providing some samples for research, so we can find better ways to keep everyone healthy.
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Understanding cancer causes and prevention methods
This study is looking for people to help us understand what causes cancer and how we can prevent it, so if you join, you'll fill out some surveys and give a small sample of your health information to help us find better ways to keep everyone healthy.
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Targeting specific cells in the pancreas to improve Type 1 diabetes treatment
This study is testing a new therapy for people with Type 1 diabetes that uses specially designed immune cells to help protect the insulin-producing cells in the pancreas, which could lead to better diabetes management and control.
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Understanding the genetics of molybdenum cofactor
This research explores how a vital substance called molybdenum cofactor, or Moco, works in the body to help us understand a rare and serious genetic condition.
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Understanding how ovarian cancer responds to platinum treatment
This study is looking at how the most common type of ovarian cancer responds to platinum-based chemotherapy by exploring changes in the surrounding tissue, and it's designed to help improve treatment for patients who struggle with this tough disease.
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Understanding how specific genes contribute to the development of bone cancer in children
This study is looking at how certain genes, especially p53 and Rb, affect the growth of osteosarcoma, a serious bone cancer that mainly affects kids, to help find better treatments for patients.
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Understanding how neural progenitor cells develop in the brain
This study is looking at how brain cells develop in the early stages and how a specific protein called ZBTB7A might play a role in this process, which could help us understand conditions like autism and find new ways to help those affected.
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Understanding how primary cilia affect brain signaling and function
This study is looking at tiny structures in our brain cells called primary cilia, to see how they help our brain respond to signals from the outside world, and it aims to find new ways to help people with brain issues caused by problems with these cilia.
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Understanding how nerves in tumors affect pain in head and neck cancer
This study is looking at how certain nerve cells in head and neck cancer tumors might affect pain differently in patients with HPV negative tumors compared to those with HPV positive tumors, and it hopes to find new ways to help manage that pain.
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Creating a mouse model to study and treat high-risk rhabdomyosarcoma in children
This study is creating special mice that have a type of cancer similar to what some kids get, called rhabdomyosarcoma, to help scientists learn more about what causes it and how it grows, with the hope of finding better treatments for children facing this tough illness.
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Understanding kidney diseases linked to Alagille Syndrome in children
This study is looking at how certain genetic changes related to Alagille Syndrome affect kidney health in young children, especially those under 5, to help find better ways to prevent and treat kidney problems they might face.
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How maternal diet affects heart health in children of diabetic mothers.
This study looks at how what mothers eat during pregnancy, especially if they have gestational diabetes or obesity, can affect the heart health of their children and even their grandchildren, using rats to find ways to help improve heart health for families at risk.
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Exploring how genes and their functions can be analyzed using advanced technology.
This study is exploring how our genes work and how they affect health, especially in cancer, using the latest technology to help find better treatments for patients like you.
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Support for studying protein interactions in pediatric health
This study is all about helping scientists who are looking into children's health by providing them with tools and support to better understand how proteins work together, which could lead to new treatments for childhood diseases.
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A center to support pediatric biomedical research and training.
This study is all about creating a special center in South Dakota to help scientists learn more about children's health issues, so they can find better ways to understand and treat diseases that affect kids.
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Understanding and treating diseases in children
This study is looking into how certain diseases in children happen by examining how their cells grow and change, and it's designed for scientists who want to better understand these conditions to help kids live healthier lives.
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Investigating how molybdenum cofactor affects metabolism in animals
This study is looking at how a special nutrient called molybdenum cofactor (Moco) helps our bodies work properly, especially for people who might have problems because they don't have enough of it, using tiny worms to learn more about how Moco is made and controlled, which could help find new ways to treat related heal
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A summit for rare disease awareness and collaboration in the Great Plains.
This study is all about bringing together patients, advocates, and researchers at the Great Plains Rare Disease Summit to share knowledge and support for rare diseases, helping everyone learn more about their conditions and how to advocate for themselves.
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Understanding how Sox2 contributes to tumors without Rb
This study is looking at how a gene called Sox2 helps tumors grow when another important gene, the retinoblastoma (Rb) gene, is missing, and it hopes to find new ways to treat these tumors that could help patients in the future.
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Training undergraduate students in pediatric biomedical science
This program gives undergraduate students in South Dakota a chance to dive into exciting research in children's health, helping them explore science careers while also encouraging a diverse group of future scientists.
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