Understanding how Sox2 contributes to tumors without Rb
Official title: Oncogenic mechanism of Sox2 in Rb-deficient tumors
Funded at Sanford Research/usd · NIH-10663177 · Data updated 2026-11-12
This study is looking at how a gene called Sox2 helps tumors grow when another important gene, the retinoblastoma (Rb) gene, is missing, and it hopes to find new ways to treat these tumors that could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | July 23, 2019 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $369,889 |
| NIH project number | 5R01CA233661-05 |
| Project ID | NIH-10663177 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with tumors related to retinoblastoma or those with Rb gene mutations.
✕Less likely to help
Patients with tumors not associated with Rb loss or those without any genetic predisposition to Rb-related cancers may not benefit from this research.
What this research studies
This research investigates the role of the Sox2 gene in the development of tumors that occur when the retinoblastoma (Rb) gene is absent. By using genetically engineered mouse models, the study aims to determine how Sox2 promotes tumor growth and maintenance in the absence of Rb. The research focuses on understanding the mechanisms behind Sox2's oncogenic activity, which could lead to new insights into cancer biology and potential therapeutic targets. Patients may benefit from this research as it could uncover new strategies for treating Rb-deficient tumors.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cancers associated with Rb loss, improving outcomes for affected patients.
How similar studies have gone: Other research has shown promising results in understanding oncogenic mechanisms in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Kareta, Michael S. — Sanford Research/usd
- Study coordinator: Kareta, Michael S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.