Understanding how ovarian cancer responds to platinum treatment
Elucidating spatiotemporal dynamics of nascent extracellular matrix in response to platinum treatment in ovarian cancer
['FUNDING_R37'] · SANFORD RESEARCH/USD · NIH-11128060
This study is looking at how the most common type of ovarian cancer responds to platinum-based chemotherapy by exploring changes in the surrounding tissue, and it's designed to help improve treatment for patients who struggle with this tough disease.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD RESEARCH/USD (nih funded) |
| Locations | 1 site (SIOUX FALLS, UNITED STATES) |
| Trial ID | NIH-11128060 on ClinicalTrials.gov |
What this research studies
This research investigates how high-grade serous ovarian carcinoma (HGSC), the most common type of ovarian cancer, reacts to platinum-based chemotherapy by examining the changes in the extracellular matrix (ECM). The study employs advanced technologies to track the dynamics of newly synthesized ECM in response to treatment, using engineered cancer co-cultures and patient-derived tumor samples. By analyzing these changes, the research aims to uncover mechanisms that contribute to chemotherapy resistance, which affects a significant number of patients. The findings could lead to improved treatment strategies for those battling this aggressive cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with high-grade serous ovarian carcinoma who are undergoing or have undergone platinum-based chemotherapy.
Not a fit: Patients with other types of ovarian cancer or those who have not received platinum-based chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for ovarian cancer, potentially reducing recurrence rates and improving patient outcomes.
How similar studies have performed: Other research has shown promise in understanding the role of the extracellular matrix in cancer treatment responses, suggesting that this approach could yield valuable insights.
Where this research is happening
SIOUX FALLS, UNITED STATES
- SANFORD RESEARCH/USD — SIOUX FALLS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DE LA PUENTE, PILAR — SANFORD RESEARCH/USD
- Study coordinator: DE LA PUENTE, PILAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.