GPCR signaling: how these receptors talk to many proteins in the body
Official title: Structure and Function Studies of GPCRome
Funded at Sanford Research/usd · NIH-11345338 · Data updated 2026-11-12
This project looks at how GPCRs communicate with different G proteins to influence many body processes and drug responses.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | July 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $415,000 |
| NIH project number | 5R35GM156391-02 |
| Project ID | NIH-11345338 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with conditions treated or influenced by GPCR-targeted drugs may benefit from improved therapies in the long term.
✕Less likely to help
Direct patient benefit may be limited to future drug development; no immediate changes to patient care are expected.
What this research studies
GPCRs are key players in many bodily signals and are common drug targets. This grant aims to map how GPCRs engage different G proteins beyond traditional categories, offering a clearer picture of signaling networks. The research will use advanced computational analyses and experimental approaches to understand the complexity of GPCR-G protein interactions and their implications for therapies. If successful, the work could refine how new drugs are developed to be more precise and effective.
Why it matters
Potential benefit: Better understanding of GPCR signaling could lead to smarter, more effective medicines with fewer side effects.
How similar studies have gone: Previous work shows GPCRs can couple to multiple G proteins; this project builds on and extends those findings.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Masuho, Ikuo — Sanford Research/usd
- Study coordinator: Masuho, Ikuo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.