Understanding how primary cilia affect brain signaling and function
Official title: Identifying regulatory networks that govern primary cilia remodeling and neural signaling
Funded at Sanford Research/usd · NIH-11092922 · Data updated 2026-11-12
This study is looking at tiny structures in our brain cells called primary cilia, to see how they help our brain respond to signals from the outside world, and it aims to find new ways to help people with brain issues caused by problems with these cilia.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Research/usd NIH-funded |
| Lab location | 1 site (Sioux Falls, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $415,000 |
| NIH project number | 5R35GM151229-03 |
| Project ID | NIH-11092922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive decline or related neurological conditions linked to cilia dysfunction.
✕Less likely to help
Patients with cognitive impairments not associated with primary cilia dysfunction may not benefit from this research.
What this research studies
This research investigates the role of primary cilia, small sensory organelles found on most vertebrate cells, in converting external signals into cellular responses, particularly in the brain. The study aims to uncover the mechanisms that regulate the formation and remodeling of these cilia and their impact on neuron structure and connectivity. Using advanced techniques such as unbiased screening, mouse models, and cutting-edge microscopy, the research seeks to identify potential therapeutic targets for conditions related to cilia dysfunction, which can lead to cognitive impairments. By understanding these processes, the research hopes to provide insights into how cilia contribute to brain health and function.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for cognitive dysfunction and related neurological disorders.
How similar studies have gone: While the role of primary cilia in various biological processes is established, this specific investigation into their impact on neural signaling is relatively novel and has not been extensively tested.
Where this research is happening
-
Sanford Research/usd
Sioux Falls, United States Active
Researchers
- Principal investigator: Loukil, Abdelhalim — Sanford Research/usd
- Study coordinator: Loukil, Abdelhalim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.